#300 Louisa Nicola - Peptides, Cancer and the Deadly Habits That Lead to Alzheimer’s

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Oh, it's so good to be here. It's good to have you.

“So yeah, I saw you. I think it was on Diary of a CEO's podcast and you were talking about Alzheimer's.”

And I've been looking for somebody to talk about Alzheimer's because that in cancer are pretty much my biggest fears of life, and my grandpa died from Alzheimer's. And it seems to be growing more rapidly. I just read something.

These are seven million Americans have Alzheimer's and by 26, it'll be almost 14 million.

More. Yeah, it's going to triple by the year 2050. Holy shit. So currently the statistics are around 60 million people worldwide have that disease. So it's going to triple by the year 2050. Man. Yeah. Well, I want to dive into what's going on in the brain, how it comes about, what we can do, all these, there was some new, I think we sent you this new study they're doing in mice that 40 hertz. Yeah, 40 hertz.

What is, do you know what a rife machine is? No. It's like holistic type stuff. It shoots frequency through your body. Oh, yes. Yeah. And there's a lot of science. I love that you said it was a mouse study, right? It was done in mice because it's very hard to replicate these studies

“in humans. Although it's a, you know, I think it's really phenomenal. I think using these”

40 hertz, you know, whether it signals from light or sound, I think it's actually, you know, really great for the brain. It is good for the brain. Yeah. And so do you know what brain waves are? No. So brain waves, we've got different frequency bands in our brain. So when our neurons

fire together, we've got around 87 billion neurons which we're going to go through everything with

the audience. But just as a helicopter overview, when they start to fire when we're doing particular tasks, they shoot these oscillations of brain waves and they're good things. And we can map those out using an EEG. And we can map out whether the brain is using alpha waves, beta, gamma, delta brain waves. Generally, the delta brain waves are these big, luscious, big brain waves that occur during deep sleep. So we know you're in deep sleep because

what we see on an EEG are these big brain waves. So we know they're delta brain waves. But these gamma waves are around 30 hertz to 100 hertz. And these tend to happen when we're in deep, focus or deep concentration or deep thinking. So, and it generally happens around the prefrontal

cortex area. And in the hippocampus as well. So it is said that these are the first oscillations

to deteriorate during neurodegenerative diseases. So when we are... Those brain, those particular brain waves. The gamma brain waves, yeah, because we lose our processing speed, we lose our thinking capabilities, right? So those neurons don't fire therefore we don't get those oscillations. Now, it's been said that we can mimic certain oscillations from the outside world. It's actually called entrainment. Meaning that our brain can mirror the 40 hertz signals that are recurring

outside of us. So if we can get into this place of whether it's through lights, which I love, or whether it's through sound, if we can mimic our brain waves, if our brain waves can get on that 40 hertz bandway, then it can start to heal the neural pathways that are degenerating. So that's where that comes from. And look, it's... I think it's going to be the next big thing

millions. I just saw a new company that has raised around $200 million to come up with a

device that mimics this. Interesting. I just saw you post something on your LinkedIn. It was like...

“It was that. Yeah, I saw that. Yeah. And I thought it was really fascinating. I think look,”

there's whole binoral beats. Era took place in the last five years where you could download an app and you could look at the binoral beats and kind of mimic this. But I think now we can start to you know, move into more replication in human studies. And so this is this... I found this on Twitter right after I saw you on diracy. And I said, MIT researchers cleared 50% of Alzheimer's plaques using 40 hertz sound waves. So this... So what is the... So if the 40 hertz is...

Where does the plaque go? Yeah, it's so basically we're going to have to do a whole,

you know, we're going to have to learn all about this. But that tweet wasn't entirely true because the study they're referencing actually used both light and sound. And they cleared it out in a mouse model. So when we accumulate these amilloid beat-up plaques, when they get cleared out, which we have the ability to do during deep sleep, by the way, they get cleared out through the perivascular space and into the lymphatic system. Okay. Yeah. Okay. So they're able to speed that up.

I have a theory, along with this. And the theory is that along with sound and light, vibration, I believe, is going to take place as well. Being able to vibrate there like your lymph nodes in your face to clear the plaque out. What do you think that? I think that because new research has just shown in mouse again, um, mice again, that the amilloid beat-up actually accumulates in the nerves. So we've got two nerves that come into the face, the trigeminal nerve and the facial nerve. They just sit

just imagine here, right? And they come from their cranial nerve, so they come from the brain, and they go into the nerves here and they're found that when they vibrate these mouse models, they can clear out amilloid. And so this is now giving rise to, well, if I wake up every day, and I start doing facial massages, can I clear the amilloid? Wow. Wow. What is the amilloid do? All the amilloid is it's one of the hallmarks of Alzheimer's disease. It's one of the things that's

getting in the way of your brain functioning. And when it actually accumulates in what we call

“plaques, these hard plaques, that's what causes neurodegeneration. That's what we see. If you look”

at a brain scan of an Alzheimer's disease patient, you can see their brain is shrinking all his holes in their brain on neuro imaging because these plaques are getting in the way. They're stopping the brain, the signals from cell to cell, which causes the collapse of your entire network. The whole man. Okay. But we'll go through all of that. Okay. Okay. I got a couple of random questions too before we get really good gone, but I just, I just read something this morning and I didn't even

get to get the whole article because I was on my way down here, but I just ran across it. It was talking about that I think it was saying there was a peer reviewed study that said, people that use AI are seeing a cognitive decline because they're not, do you know anything about this? Oh yeah, it's this brain rot error. Behead of brain rot? It's pretty sure I have it. It's all right. I'll tell you what, I'm actually afraid of kids right now because this brain rot error

is basically what you're doing is you're looking and scrolling at dumb content, right? Content

that is not allowing you to think and your brain which will learn is basically it uses the analogy use it or lose it and if you don't provide it stimulus, right? Just like your muscles, you know,

“you go to the gym, you need to lift weights for a muscle to grow. If you don't do anything,”

the muscle becomes dormant and it weighs away. Your brain is no different. So when you are not using your brain effectively, you're not providing it the stimulus, what happens? Well, you end up with cognitive decline in the end because you're not training it to think, to critically analyze any more and I see it for myself actually. I was a mathematician, right? That's how I got into this entire space and I told you, Sean, like back in my early 20s, I was doing trigonometry. I was using

sine cosine without a calculator. I could do large mathematical equations. Now I put everything into Chatchy BT because, you know, even when I'm working out the tip on a bill, that's how like sometimes

because I'm not using it anymore. Okay. Okay. So could that, do you think that could lead to

“to Alzheimer's disease or? Yeah, I definitely think so. I think that if we don't use AI effectively”

and we're using it for this brain right error and the more times it was spending on social media, scrolling this dumb content, we are leading ourselves towards mild cognitive impairment, which is the pre-dimension state. And once we're in there, we can't get out of it and it's just a slippery road down to Alzheimer's disease. So could that alter your genes? I'm just curious. No. It wouldn't like evolution or anything like that. I've actually been thinking about this

often. What's our brain going to look like due to evolution in the next 1,000 years. You can map this out using AI and it's quite interesting. It actually shows larger brains. But I don't think it can alter the genes. I think it can just just change the functionality. Okay. Okay. Okay. It's going to be a fascinating conversation. Let me give you an introduction here real quick. Louisa Nicholot, an Australian-born neuropsychoso. Neurophysiologist. Neurophysiologist human

performance coach in clinical brain scientist who has spent over 13 years studying the brain, founder and CEO of Neuroathletics. Host of the Neuro Experience podcast and have published peer-reviewed research in leading academic journals. You were on track for the Olympics as a professional triathlete representing Australia on the world stage until a car hit you and that changed everything. Your mission now is to end the Alzheimer's disease. So I'd like to kind of start with with

the Olympics and the accident and I would like to know what happened and how how that got you into this. I think as an Australian, so my parents were born and raised out in Cyprus and then they migrated to Australia and I think and I was born in Australia as an Australian we all learn how to swim. It's part of our curriculum to actually move forward and in a

“particular subject pdhp and ur8. You have to be able to swim a certain distance with your clothes on.”

So I was always a natural swimmer gifted swimmer and for fun I decided to enter a triathlon

and I ended up winning in my age group. As you do I didn't have the best bike and running skills but I won and then that led to me led to my career in being a triathlete. So I had a team. I trained rigorously Sean. I was training anywhere from 30 to 40 hours a week. We would do morning sessions, midday sessions, afternoon sessions. I lived and breathed triathlon. I only spoke to my teammates. I had my coach obviously who was an ITU international triathlon union special trained coach and

he said we're going to get you on track for the 2009 Beijing World Championship series. So in order to qualify for something like this and they take three from every in terms of like gender

“age group from every country. So you have to make top three. And in order to do that in Australia”

you have to race at least 10 races in that season and get a podium finish. So I did that and I qualified for the Australian World Championship category. So I was off to Beijing and it was probably the greatest time of my life. You know, you're in your I think I was around 23. I'm correct and maybe 24 year at year your peak cognitive health you are. You don't have too many demands. I was living at home. I didn't have any expenses. Really so my entire

brain was just set on triathlon. And two weeks prior to racing and going to Beijing we set out to do a 200 kilometre bike ride and I went out to do this with two team mates and do you know anything about triathlon? My gosh. So when you're on the road and you're traveling at a certain speed I think we're going at around 30 to 40 kilometres an hour and we were getting to the 100 kilometre mark and we had to do a U-turn and this was on a road and we do something where we

we tailgate each other. So we were doing two kilometres at a time and we'd switch. So it was my

turn I was on the back and the back the the back cyclist is always the one that's directing

because you have to look behind to see if there's any cars and instead of you know going on to

road bike lane and then a guardrail. So we were traveling up this bike lane and I looked behind

“I saw a car and I said hold up there's a car so we stayed in the we stayed in the bike lane.”

We saw the car go past us so we merged into the lane. I saw another one coming really fast. So the speed limit at that time was 80 kilometres and he was coming up really fast so I signaled to my teammates let's get back in the bike lane he's going fast. As we were getting into the bike lane the driver who was 85 years old traveling around 120 kilometres in an 80 kilometres own he caught out he caught us and he was looking at us and he wasn't concentrating

away he was going he actually followed us just by pure like I don't know oh man pure signal and because I was on the back he slammed me into the guardrail and then my bike obviously clicked to the

boys the first one went flying like a couple hundred meters up the second one his bike snapped and

I was actually squashed between the guardrail and the car so I had to fall for my title unfortunately and I was devastated I was in hospital I had surgeries my leg was in a cast I broke a few bones and so I was out he had dementia then yeah well to be honest we don't know what he was doing he was very shocked himself I don't know what he had been driving for at least two and a half hours without a break and I don't know if it was clear that he had dementia but now that I look back

“you know I think to myself like A how lucky was I B it could have been worse but what was he thinking”

so I was in a cast and that's where I had a major you know intersection in my life I felt like I was married to the sport and like I just it was just taken away from me so there's a bit of heartbreak I wasn't going to training anymore I lost my sense of identity and purpose which I found you know I had to throw myself into my studies so through myself into medicine and science at that time but funnily enough I actually was so determined to requalify for the 2012

championship series in Auckland so I did that right on I did that and as soon as I crossed that finish line I called it quits I haven't been on a bike since right on yeah

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“everything's just fine that's how it's always gone for me with standard checkups you get a quick”

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little fleck like that right seems pretty cool it is pretty cool got a silence it in another lifetime I did gun reviews for a living proprietary magazine supposedly the best engineering in the world when that breaks your and now we're bringing it back

in this market now yeah well let me tell you it's you know you can study human performance

“you can study exercise physiology but I've been there and I've done it you know you you see a lot”

of people now on social media talking about brain performance and and what it means to perform at elite level and it's good in theory to read a textbook or to read a science study but unless you've actually been there and done that you can't really grasp what that means and at that time of training I did everything to a T like I was doing V02 Max test so you know the whole world is called on now is doing those you know in 2007 2008 we didn't have data back then to show

what our heart rate was we were using metronomes you know I would clip a metronome to my headband

to figure out you know what's my pace we didn't have watchers and heart rates like every time

I ran a lap my coach would you know check my pulse and then we'd determine whether we know through a calculator like what percentage I'm running at so when you know that hardcore raw data and you can translate that into science today it's it's so much different than just reading do you wear any of those wearables I do when I'm training I wear a garment watch and I wear a heart rate monitor just because it's so natural to me so I can check what my heart rate is I've recently

taken off my ordering why did you do that which I haven't done like I've got a dent in my my finger for that I did that because I'm so sick of it telling me that I'm sleep deprived because I'm in a stage of my life now where I'm traveling a lot it was providing me no I tell you it was for somebody who's so deep on like biomarkers and numbers it was providing me more stress and I just said that's it really yeah I don't have well I've been thinking about using one but I don't

just don't know if I want all my data in the in this I get paranoid well guess what they just a lot of people don't know there's another reason I took it off um aura is now selling people's data really yeah not whoop but ordering it's another reason why I took it off so all of your data in terms of you know women are tracking when they ovulate women are tracking them menstrual cycles you've got evidently your your age your date of birth everything is stored in here your daily

habits and it tracks where you are because you you set it to going for a run it shows you where you've ran so it's tracking everything and they're actually selling that data and this is publicly available news well who would they sell it to what would they get large corporations in insurance companies probably pharmaceutical companies is it tied to you directly yeah it would be tied to like your daughter is now stored and being sold to companies I can only imagine what that can

pose as a risk for you can this stuff help to if you have let's say have years of data you know and you're everything that that kind of stuff I mean if you gave that to a doctor with that help and any that's the that's actually why I wanted you determine yeah they've so I

“I don't wear the warp band I mean I think I might go I might go and do that actually but”

they've got this new thing on there which shows if you have atrial fibrillation and it can detect whether you have a fibrin a fibris one of the biggest risk factors for a heart related event or a stroke so I think that's pretty cool yeah yeah right on a couple things to knock out here of a patreon account okay cool and um they're the reason I get to sit with you here today so they get the opportunity to ask every single guest a question and this is from Corey Powers

from Nero psychology standpoint what do we know about the chronic exposure to operational stress and professions like the military and policing affects brains aging over decades and are there specific evidence based strategies like resistance training or metabolic interventions that can help maintain cognitive longevity for people who have spent their careers in those type of

“environments yes and thank you for that question I think it's really um prominent so there's many”

things that play here first of all the ongoing threat and stress to your brain over as substantial

amount of time can cause some form of neurodegenerational accelerated neurodegeneration but if you talk about the military then we have to bring up concussions we have to bring up TBI's and you've probably heard of CTE chronic traumatic and so forth and this here is actually CTE and Alzheimer's disease literally if you look at them on autopsy studies they look identical right so there is some

in theory I don't agree with what's happening there however if you have if you are at that state now where you've gone through all of that you just have right now to intervene you can't go back in time there's no reversal of any cognitive decline so you can intervene with metabolic interventions one of the greatest ones that you can intervene with is putting your brain in a state of ketosis I'm so fascinated right now on the research of ketones and what they're doing to help

with brain fuel so having exogenous ketones is one thing that I'll tell you you're the person who asked another thing yes evidently resistance training exercise nutritional interventions staying away from

“sugar and sleep I think in this instance sleep when you're trying to recover we'll probably”

outweigh exercise and I never usually said I always say that exercise outweigh's everything but

when you're trying to really recover and regenerate a damaged brain you need somebody to be sleeping I mean that's a big challenge for veterans I'm a veteran I sleep like shit I think pretty much anybody that's probably seeing any type of combat sleeps like shit yes D PTSD traumatic brain injury I mean you just always switched on business stress I'm sure you deal with a lot of business stress I mean it's just the brains always running

especially mine it's just it's going a thousand miles an hour all the time I wake up at the middle of the night thinking about whatever's bothering me and and so so if that's I mean yeah it it almost like when you say well sleep better it's so I go shit that's probably not gonna happen and and this is the hard thing right because then you also get new mothers and it's a what's a new mother going to you can't just tell her sleep more right you know they

hearing new mother for the next 10 years of your life with you I have one child too or more you're going to be sleep deprived right so I know the science and then putting it practically is a completely different story right but there are certain things you can do for sleep interventions and it really comes down to instead of just sleep better it comes down to let's locate what your problem is and normally when it comes to sleep people have two problems I'm having trouble

falling asleep I'm having trouble staying asleep and they then provide you know the interventions

“that you need to start attacking so if you can start with just looking at your sleep environment”

I always say you have to train for sleep and it comes down to like what are you doing

at 8 30 pm every night what time do you go to sleep how do you prepare your mind for sleep for somebody like you who's got this racing mind outside of supplementation which would actually give you a lot of benefit you could start you know warming up for sleep like getting rid of your phone not remailing anybody not having any crazy conversations sleeping in a in a dark room setting the lights at like 8 39 like dimming them putting just red lights on to get your body

ready for sleep putting just red lights on I like to use red lights or dim the lights will just have floor lights at home because it signals to my brain hey we're getting ready for sleep melatonin starts to rev up from the pineal gland starts to release it in small doses

“if you've got the lights on at night your brain thinks that you're awake”

it can't go from awake to sleep you want to have this transitional moment right so you have red lights all over your house at night time yeah kind of looks funny I'm living New York City as well and some people walk upon they say this red light apartment signals the wrong thing yeah I see yeah um yeah that's uh that's a challenge that I've been thinking about a lot and I want to dig into a little bit more especially when it comes to psychedelic therapy

yeah but uh but before we get there everybody gets a gift wow these those are our vigilance elite gummy bears oh I love actually don't try athletes love gummy bears yeah well what if depends on what's in them well nothing good okay I can't wait to have these I I've I've travel a lot so this is gonna help you thank you welcome well let's not have been I just want to read a couple of uh numbers when it comes to all

time or so people understand how serious this is an estimated 7.1 Americans are currently

living with all time or symptoms projected to nearly double to 13.9 million by 2060

what you said actually will triple by 2050 globally over 50 million people have dementia expected to hit 150 million by 2050 someone in the u.s develops all timers roughly every 65 seconds it

timers patients are women why is that tie and estrogen menopause and hormonal shifts so

“think before we go any farther can we just talk about what is Alzheimer's dementia”

and how does it happen yeah I love that we're talking about it because I just want everyone

to know this is not a disease of old age we used to think it was and when I first started

in a hospital working in a hospital I thought Alzheimer's and dementia was just a disease that you got in your 70s and 80s is this even an organic disease what do you mean by organic is this so I've read several of our articles and say cancer is not an organic disease it's from all the pollution and shipping of the earth Parkinson's is a man made disease Alzheimer's disease is a preventable disease in my opinion it is also a man made disease

Alzheimer's disease let's talk about dementia so dementia is the umbrella term it's not a diagnosis it's not a diagnosis right it's a term that we use to describe symptoms it actually comes from the word "demented" so as you get older and you lose your processing speed that's your ability to think fast right speed of decisions you get slow, slow thinking and your memory starts to decline these are you know these are all cognitive functions we use them every day when they start to

“decline or become demented that's what we call dementia so that's what dementia is underneath”

dementia I think of it's the umbrella term underneath it sits various forms of dementia we've got Parkinson's dementia right so if you have Parkinson's disease you have some cognitive

demented states so you have Parkinson's dementia vascula dementia that's the second greatest

form of dementia we've got Alzheimer's disease which is called Alzheimer's dementia what is vascula dementia that's when you have the so the vascula system of the brain that's when that starts to deteriorate it's when all the blood vessels are still not getting blood flow correct yeah it's severely attacks the blood vessels of the brain okay so you've got dementia with Louis bodies now the part that we can't help right when it comes to genetics there's around

30 to 40 different genes involved in all of the dementia and there's only really three right that if you genetically get these from mummel dad you will get Alzheimer's you will get a form of dementia right now you know Bruce Willis he's got something called a fronto temporal dementia right so this is generally when we have a mutation in specific genes right so the genes I'm talking about are we've got precyline one precyline two in the amoloid precursor proteins

when it comes to our genetic code we've got mutations and then we've got risk factors risk genes

“so let's take if you've got a genetic mutation on chromosome 4 that's how you are born you will”

get Huntington's disease you will get it we can't change that for you and that's that is it but for Alzheimer's disease specifically not fronto temporal dementia not dementia with Louis bodies for Alzheimer's disease there's no genetic mutations in the genes there's only risk genes right so meaning that you don't have to have these risk genes and you can have these

risk genes but it doesn't mean you're going to get it okay the problem is 95% of all

Alzheimer's disease cases were driven through lifestyle really yeah there's only around three to five percent of the total Alzheimer's disease patients or cases that possess the risk factor genes do you say only three to five percent of all Alzheimer's disease cases were driven through genetics meaning that 95% of all Alzheimer's disease cases were driven through lifestyle interventions and factors I feel like that's good news it's good news it is

because it means that you have agency over your brain it means that you have agency over this disease it means that you don't have to be scared like you mentioned earlier I am not scared of Alzheimer's disease I'm scared of cancer because this is something that I don't know anything about a it's also something that can just sporadically happen no matter how good you are with your diet and exercise but when it comes to Alzheimer's disease in the brain and we're going to have a look at the

get this disease or not and those choices start in your 30s and they get accelerated in your 40s

“and 50s and then in your 60s and 70s that's what will determine how well you lived in your 30s”

and 40s so these risk factor genes okay these are called the APOE gene so APO lipo protein E we all have them right and they come in pairs because you have one allele from mum and one from dad now we've got APOE 2 they're just different variants of the APO lipo protein E gene but we've got APOE 2 APOE 3 and APOE 4 so you have these I have these and if we have a copy of the APOE forging it read just one copy right you could be E 3 E 4 if you have one copy it raises your risk of

getting the disease by 2 to 3 fold so you have an increased risk increased risk right if you have

two copies you could be an E 4 E 4 carrier now 25% of the population has at least one copy

“right 25% if you have two it raises your risk by 10 fold if you are a woman it raises your”

risk by 14 fold 14 folds if you have two copies of this gene what is the regular risk one out of do you know how many so around 2 to 3% of the population has two copies okay so the Australian actor Chris Hemsworth has two copies of this gene I saw that they made a documentary series or something about that they did because he doesn't want to lose his mind so he has two copies

yeah it doesn't mean that he's going to get this disease in fact there's a landmark study that

was done in Africa which actually showed that they've got a high population of APOE 4 carriers right because it's genetics a huge population but then the lowest population of Alzheimer's disease cases in Africa yeah why is that probably because they're running around all the time eating better probably have access to a hardware life yeah so they have to be more active yeah they've got a better they've got a they've figured out something that they that we haven't in the

US what do you think that is I think it comes down to lifestyle I think it comes down to primarily stress sleep better sleep habits better food access to food crops organic foods they're not spraying their foods with all the pesticides and then their daily living you know activities of daily living that's what we call it in academic research like what are you doing every day to increase your steps what are you doing every day to exercise what are you doing every day to

keep your brain active so I think that they're doing more of that we are so

“technology driven in this country and I think that that's what's getting in the way whether it's AI”

whether it's sitting in our in front of a computer screen working every day and that's preventing us from sleeping better eating better food exercising et cetera could it be could it be a ethnicity issue is it higher in white people than it is in black people no I mean it's you know it's said that's higher in ethnic you know in the European countries and this is all just because of genetic you passed down your genes by the way you can test for this you can test if

you've got if you're an apo e4 carrier or not some people choose not to because they believe while I'm doing everything I can anyway and while and that's true I believe that everyone should get tested because you want to know if the bus is coming right and if the bus is going to hit you because then you can intervene even better than harder okay yeah okay so what would let's let me let me introduce Henry okay so but everybody watching so this is Henry and I'm going to just

perform a cranial to me right now we've just taken a skull and I just want to use the brain just to probably show you so the brain is around two pounds right and it actually feels like hard gelo like tofu right and it consumes 20% of all the energy that you consume every day so it's a hungry organ right and it's comprised you've got two hemispheres of me who can do this so you get two

called the cerebellum which is Latin for mini brain and here is the brain stem the brain has around

“87 billion neurons neurons are brain cells we've got different types of brain cells we've got”

glial cells as well which we'll go into but here's the fascinating part see these red vessels here the brain is the most vascularage organ in the entire body actually if you were to pull apart all of the blood vessels in your brain which comprise of capillaries veins and arteries right if you were to pull them all apart it would span 400 miles wow so it's it's a vascular network tightly danced in this two pound blob right and these brain cells are responsible for

everything you do right everything you do everything you are everything you think everything you feel comes down to how your brain is functioning that's all so there is you know the reason I got into

this in the first place was when I was studying mathematics there was a neurophysiologist that we

“had to study and back then I was like what's a neurophysiologist and his name was Warren McCollock”

and he teamed up with a mathematician the his last name was pits and they were able to come up with the algorithm for how neurons fire it was phenomenal it's such beautiful work and in fact that algorithm and that mathematical equation is what printed the neural network that we know today which is AI wow yes and it's so beautiful and he's got a phenomenal book which I've like which I read all through doing my thesis but when I figured this out you know I remember talking

to my my professor and he said to me he said McCollock knew that when that that neurons either fire or they don't and it's dependent on a mathematical code so your neurons either fire together so neural plasticities when neurons fire together they wire together so we knew that

“but neurons are either on or they're off and when they're off that's what ends up becoming”

neurodegeneration and deteriorating your brain so we've got 87 billion neurons which are being

fed from the vascular system right these little ones that you see here on the outside of the cortex are capillaries and Australia we call them capillaries they're one cell thick so they're not like arteries so arteries are thick right they're like these tubes and they're supported by a muscular outer layer right so they can handle they're like pipes right so they're big and we have branching off those from the from the egg order and going up into the brain but these little ones are the

first things to die right they die primarily when we have an insulting your own an assault like a TBI if you get a TBI you're most certainly going to be breaking these little capillaries because they're so tiny they're so fine these are the first things to go with hypertension high blood pressure right so one of the best things you can do is by yourself a 25 dollar automatic blood pressure monitor on Amazon which can measure your blood pressure and you want to maintain the

120 over 80 gold standard anything above that you know that you are starting to break your brain the small vessels of the brain so then the next question is well the ways or if we you know let's just say we kill off these little capillaries what happens well these capillaries are feeding the the neurons in that area if you cut off its blood supply you cut off its oxygen and its nutrients so the neuron itself can no longer survive so what does it do does correct and then you

think well there's 87 billion neurons you know am I going to feel it well this is why it takes 20

to 30 years to feel your first symptom of Alzheimer's disease one neuron you're not going to feel it but that one neuron stops communicating with the the nearby neuron and then that stops communicating with the nearby neuron this takes you know when you stop when they stop accumulating in a small cluster that's when we start to feel symptoms of dysfunction you know if it happens on the left side maybe you're getting in the way of your language processing this is what people notice

well the first symptoms to go is memory specifically short-term memory forgot my keys what's that person's name you're walking to a room why did I come in here what was

things short-term memory long-term memory doesn't really get affected so it's the first thing to go

“and that is because let's just perform surgery here that is because we have a deep structure in our”

brain can call the hippocampus the hippocampus is a seahorse shaped structure it actually means seahorse in Latin and it lives as you can see it's so deep it's part of what we call the limbic system the the temporal lobes are here behind your ears and it lives deep in there and it's the first thing to go during our sinus disease so that starts to deteriorate the hippocampus holds all of our memory formation our memory consolidation this is where we learn new things as well so that is it's

very susceptible to oxidation meaning that if it gets stressed it becomes oxidized that's when we start to kill the neurons in that area so if we start to kill the neurons in that area and they become dysfunctional then I'm sure term memory starts to fade we've all seen it the department of war is

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i try to justify why things are happening to myself all the time but yes i forget people's names i don't forget people's names my family my team do you know what's friends when those memories are formed in the hippocampus they get protruded out to the cortex and that's where they live this is why you can get somebody with Alzheimer's disease right in their end stage

“and they'll remember their daughter right although become lucid and they'll remember their wedding day”

but the short-term memory it's also important to differentiate between short-term memory loss and just pure stress and lack of concentration in the moment of you know knowing that person's name but you know you're a vet you've been i'm sure you've been involved i mean have you had a TBI you've probably had multiple right and who knows what happened in that moment you know

the most important stage right then is 72 hours of that insult an insult is a hit to the head

what happens within that 72 hour time frame which is why the concussion protocols at the NFL really matter like what are you doing to preserve this person's brain after they've taken a hit right you can stop the process immediately if you do certain things in that 72 hour period but you know we don't know what happened back then for you and then did that you know did that evolve

and you're right we haven't seen any of your images i don't know if you've done any like MRIs or anything like that yeah i don't want to why because i have a lot of friends with this and i'm not saying a lot of improvement unless it's psychedelic assisted therapy and that's you know and i know that you've

“taken over again yeah i think that's going to be also something big especially in the state of”

California where they're looking at this now on people with major depressive disorder you know people with clinical depression there they're going through this and i think it's great as well but also think it's wonderful to see other interventions that we could use if you knew what was happening in your brain but i forget words sometimes i'm talking about these signs they have to be right yes i mean they would be definite signs of my forms of mild cognitive impairment so when it

comes to our scientists is this is what happens right you have a you get something called subjective

cognitive impairments when you first start to notice these signs brain fog right

brain for we can't remember things and then after that if it becomes more persistent and you see it in different areas of life as well slurring of words could be a language processing issue this if you get diagnosed with mild cognitive impairment there's a test that you can take it's called the mocha test moc a you get a score out of thirty it's a free test Montreal cognitive assessment you can do it it doesn't take long if you get thirty that's great right if you're getting

like you know if you're getting around at 25 you've got mild cognitive impairment right so or even 26 mild cognitive impairment this mci state lasts around 20 years

and the problem is it accumulates and accumulates it's like compound interest right it's not

that you get it now and then you just go to stop it now you're on the road okay let's imagine right where we live our lives up until 25 the brain fully forms it around 25 years old

“that's it and that's why that's why that age is so beautiful you know when i was training”

like triathlon my brain is still developing it's firing 22 23 beautiful but then you are survived in those by by your age you can get hit in the head right and yes it's going to do some damage but you are survived by your growing of your brain due to your age and the healing process that takes place but at 25 evolutionarily evolution stated that's it reproduction is over and we no longer need to survive anymore so we're going to die that's evolutionarily why we

stopped growing at that age our brain but now we're living longer because of penicillin antibiotics and vaccines right so now we're living to 100 so our brain wasn't built for that it wasn't built to survive up until 100 we learn like 120 or 30 right so

we're at this critical point at 25 and that's when we really need to start to protect our brain

no good so it cannot be reversed but you can stop it you can stop the event there's snowball effect no you can slow it down you can slow it down yeah um to my date there are there is a prominent neurologist who believes that he has reversed Alzheimer's to these he written a book on it

“I think that that is unethical I think it's extremely difficult I've never seen it at”

it's never been seen in in academic peer-reviewed literature I don't believe it's true I tell people that Alzheimer's disease is a diagnosis that is similar to end-stage cancer okay yeah how so if you've been diagnosed with an aggressive form of brain cancer it's called the glioblastoma right I mean neurosurgery I work in neurosurgery and we've got a tumor board and we've got you know the neurosurgeons are constantly being you know thrown cases of

glioblastoma we know that there has a one to five year survival rate you don't really survive that that's end stage right and we don't know who's got it's not something that you can prevent it just happens right so that's the same as Alzheimer's disease meaning if you get it you have a after this you've got maybe a one or two year survival rate you start to lose everything all of your cognitive functions you don't even know who you are I've had a patient looking in the mirror

asking me who's that she's looking at home she thinks it's another person you lose your cognitive

you can do that now when it comes to mild cognitive impairment as I mentioned this is a 20 year process

you can slow the progression right so if you get MCI and we know that okay in 20 years this means you're going to get Alzheimer's disease let's make it 30 years let's slow that progression it doesn't mean you're getting off the treadmill right you get on the treadmill that's MCI

“you're going down this track doesn't mean you have to get the disease at 80 right by the way you”

don't die of Alzheimer's disease if I think it's really important for you as well you mentioned a close family member died I think it's important to know on the death certificate what it actually says sometimes it will say on a death certificate that's what it is you don't die of Alzheimer's disease

oftentimes which is what makes it so devastating is that it can die of it's ex-esphyxiation meaning

sometimes people just forget to swallow you forget to swallow or you may die of steps up so you know you get an infection you don't know it you know a lot of these patients are walking around they don't know if they've been hurt or you fall you hit your head and that's it's really sad the reason why it's so sad Sean is because out of all of the diseases it's the

“one that you lose who you are why I love it so much is because I love my life and I love learning”

and I've loved learning my entire life you know I didn't really grow up watching TV I grew up with books and encyclopedias and I read a lot and reading is one of my

pleasures and I love it so much that my brain gets to do that and I love forming memories I'll be

it with myself or with you know my loved ones and I would hate to lose those because you spend your whole life building those up for it to be robbed of a disease that was preventable right so let's keep going down down this if if I've got you right so you've got this this brain that is at the mercy of all these insults so every day when your neurons are wiring together right and every every time you produce a thought your neurons are firing together and at that time

they're producing a whole host of chemicals dopamine serotonin if they're getting produced in the right way of releasing serotonin which makes you feel happy right dopamine if you're releasing them in the right way makes you feel vigilant and it gives you that drive and that motivation to pursue your goals in the pursuit of goal setting right or it could be hormonal so it's a beautiful it's a beautiful structure some as beautiful structure in the entire

universe there is so much I don't know about it this here is called the Circle of Willis it's just how the the blood supplies shaped and it's really interesting because you've got the aorta which is this massive massive blood vessel that comes out of the heart from the aorta you've got here you've got the corroded arteries we've got one on each side and then you've got the vertebral arteries the vertebral arteries the corroded arteries supply the frontal

part of the brain with blood and the vertebral arteries supply the back part of the brain I love the system because if one system breaks down if you've had a stroke right in one of the arteries in the brain the brain has a backup system so if the stroke is happening in the posterior part of the brain that's supplying the posterior part maybe the occipital orb here which is responsible for our vision and everything that we see and how we process vision then the front

supply the anterior part of the brain the blood supply will use their backup system and immediately supply the brain with blood which is why strokes my father had a stroke in 2019

“which is why a stroke is such a heart like for you to have a stroke you have to think”

neurologically all systems broke down in the brain right so that's your brain that's neuro anatomy 101 okay okay let's talk about Alzheimer's disease so we've got all of the dimensions now what separates us like why is that the most prominent form of dementia a and what separates it from the rest of the dimensions and there's two proteins at play here we've got amoloid beta okay so if we have if we've got amoloid beta in the brain that's one of the hallmarks

of our siners disease that's how we can differentiate it from the rest of the the the the dimensions and then there's another one called tau protein now amoloid beta lives outside of the neurons tau protein lives inside of the neurons so we've got two attacks one that's getting in the way so

the cells in your in your body but then there's an axon that comes off it so think of a tree you've

got the roots and then you've got the tree trunk right so that's the axon okay and then the branches are the dendrites and then the leaves are these little dendritic spines the leaves okay the dendritic spines and the dendrites communicate with the other dendrites so imagine two trees

“form together and the leaves are touching that's how you produce your actions they're called synapses”

okay and so so when we get that pruning around of the the synapses that's what causes the degeneration and our network system starts to fail right so outside of the tree trunk in the air which is also the right cerebral spinal fluid that's where amoloid beta lives and in the tree

trunk themselves that's where tau protein lives so you can imagine first and foremost if we get

the build up of amoloid what happens well the leaves can't communicate anymore they get stuck like glue right they get stuck and then if they can't communicate in this stuck like this they just die so where does that amoloid come from what where does the build up come from I'm going to take you in history now and I'm going to give you something that's really it's going to make you

“maybe hate science or medicine or institutions which I know that's already hidden you've got”

something to say about that in 1901 the first ever this is how our scientists disease became a thing

a woman was experiencing a form of delirium and her husband thought she was crazy and she needed

to be in a psych ward so he took her to the hospital and the neurologist at that time he was around 34 years old his name was Aloy's Alzheimer and he took this patient and over a three year period he tracked all of her symptoms and he's got a book he tracked everything about hoaxy thought it was so mysterious you know what happens to her she died three years later but she came in with complaints of not remembering who people are not remembering faces and

she actually quoted I don't know who I am they couldn't understand why they just thought that she

“had delirium right she ended up dying of a of sexist like three three years later”

what they did was they donated her brain and Aloy's Alzheimer was able to look into her brain on an autopsy you know cut her brain and look under a microscope and he found these plaques right and when he scanned it and investigated it he found that it was amolid okay it's a protein it's an antimicrobial peptide right so stay with me it's just a protein peptide he found it so since 1905 there was this whole theory that Alzheimer's disease they called it after him

if you get these forms this form of delirium it's not delirium anymore it's called Alzheimer's disease after Aloy's Alzheimer and they were able to stay in these using silver staining to show that I can they've got these amolid deposits in their brain so then Alzheimer's disease became something called the amolid cascade hypothesis right in 2003 this is what we thought was else if you get a head full of amolid you've got Alzheimer's disease this is where it gets so interesting

and really frustrating in 2003 there was a scientist his name was he was a French neuroscientist Silvain Lesnar at the University of Minnesota was working in a lab to try and figure out Alzheimer's disease and he found that a specific type of amolid in the brain before it becomes these hard plaques they're soft oligomers right so they become soft and then they accumulate and they become these dense plaques but before they do that they're just these little oligomers

that are floating around and they're actually not neurotoxic right they become a monomer and then an oligomer and then when they start to accumulate that's when it becomes dangerous he realized or he found in 2003 in mouse models that these oligomers which is actually called amolid beta 56 that that is the sole cause of Alzheimer's disease so at it was so monumental in 2003 right this paper that he put out to show that we can solve the amolid cascade hypothesis

if we intervene and stop this oligomer from becoming the actual plaque right foundational do you know what happened then he got sighted two thousand three hundred times

and then the NIH put three hundred million dollars per year towards formulating or replicating

these studies and formulating pharmaceutical interventions to attack this right and this was the biggest thing in academic research and it wasn't until 2022 that they found that it was fraudulent holy shit are you serious so all of the papers he put out he he made he did yeah around 40 of his own papers what he did was they've got these western block these western

“plots that you have to put in academic research they will fake so all of the images he put into”

and by the way guess where it was first printed in 2003 the journal nature nature is the most prestigious academic journal in the world it is a high stringent journal and yet a neuroscientist at the universe and he only he only quit from tank his tanked position in 2024 he resigned or is fired this is the biggest scandal in the amolid cascade hypothesis and I'll tell you why

a three hundred million dollars went towards funding something that never existed there were never

able to replicate these studies and like labs all over the world were getting funded to replicate this amolid beta 56 they're going okay great how can we replicate this no one was able to replicate it over 20 year period right why didn't people intervene earlier this is a high stringent journal the most stringent journal in the world and yet you didn't realize that these images were manipulated

“how he manipulated them I'm not sure and when it came out you have to think what this did”

over 20 year per a a they were putting all of these patients through these phase three trials to to see if we could replicate these you know replicate drugs that could come in and clear it out what was happening during that time well nothing a like pharmaceutical companies like the spending billions of dollars for absolutely no reason we lost so much a integrity in science b integrity and peer reviewed processing and academic integrity I mean I just

it's the biggest I would say scandal that no one's really talking about I'm not sure why and it's fresh it wasn't until you know and it was a uh a scientist it was printed in 2022 like you know they went in they investigated it they found that this these images were were not real and it's just like what did we lose in that process and now we are now being faced with people losing you know trust in Alzheimer's disease research you know the NIH is now

cut the funding completely which is so sad for people now but imagine the patients who are going through you're giving these patients millions of people over the world false hope of going through these phase two phase three clinical trials damn 20 years of effort all just right now 20 years of effort yeah from this one man which I don't know what his motive was maybe it was money maybe it was prestige because let me tell you for 20 years he was

making it's now the retracted article is the most it's the second most cited retracted article

“in the entire world when it comes to medical science I think there's like I looked on it yesterday”

it's like 84,000 like I don't know yet I saw 84,000 I was like oh my god that's climbed a lot so people are now becoming more aware of it but it doesn't stop there so we have drugs now IV drugs one of them is called Lacanama okay one of them is there was one called adiacanama but that was pulled off the market right so now we've got something called Lacanama right and basically what this is it's an intravenous drug it's extremely expensive it's around 26,000 dollars and what it

does is when it's administered it goes through and it clears out the plaques from your brain but what people don't realise is when the scientists were going through the phase three clinical trial deaths were occurring and something called arria which is basically when you administer this drug

and during the phase three clinical trial it caused deaths it caused two deaths and this was never

“noted and the pharmaceutical companies just which formulated acanama which formulated Lacanama”

went through and fast tracked it to get it approved so it's still on the market I get asked every day just yesterday I have a friend of a friend who message me she said look I know you know what's going on my dad just got Alzheimer's disease and she's quite young she said my dad just got diagnosed they want to put him on this IV drug can you tell me anything about it it's the only thing we have right now in terms of pharmaceutical interventions right but when you actually have a

look in the New York Times actually posted this back in 2025 huge huge article when you look at

what it's doing a is a 26,000 dollar administration not many people can afford that you actually need four lots of it right you're taking you look at 100,000 yeah you're taking with you the plaques the amoloid beta plaques right but that what they're not reporting is that a lot of these patients who went through the trials who survived and didn't have micro hemorrhages and didn't obviously cause any death it wasn't preserving their cognitive functions so they're clearing out

the amoloid but they're still not themselves they're still not remembering things so what was a point there's still there's no improvement there's no improvement which brings me to my next thing you can have a person with a head full of amoloid and have Alzheimer's disease they've got no cognitive functions subsequently I can have the same another person same age same gender same genetic profile if you will with a head full of amoloid but they've got their cognitive functions what does this mean

it means that amoloid is not the demon but we have been led to believe that this protein which is a naturally occurring protein and naturally occurring peptide that it's not the problem we can't we need a stop focusing but pharmaceutical companies don't want to stop because they're formulated drunk they can eliminate that but that's not the problem that's like that's like putting a band-aid on it by the way you get rid of anoloid it's gonna come back

wow is that what the 40 hertz is getting rid of supposedly yes so it doesn't do anything so I mean it gets rid of it so what we're doing now is what we're trying to say is and it's like let's let's give a financial analogy it's like going and spending so much money on a credit card you're not thinking about anything over a 20 year period and then it creeps up to it's okay you're billions of dollars in debt what now and you're like oh I don't know

but you were warned about this 20 years ago you've that compound interest has been accumulating so

the problem isn't amoloid the problem is why is the amoloid accumulating in the first place

so what is amoloid beta well as I mentioned it's an anti-microbial peptide your brain is so strong

“remember prior to anti biotics and penicillin it had to survive so how does it survive evolution early”

well amoloid actually lives in your neurons and it actually gets ejected out of the neurons in the event of an attack amocrobial attack so think of a virus right or pathogens that get into your brain how does the brain protect itself because if the pathogen gets in the brain it starts to attack the neuron the neuron smart it's like I need to protect myself so what does it do it releases amoloid and the amoloid goes it traps the micro or the virus it engulfs it and it kills it

this is like what white blood cells do with cancer cells it detects cancer goes through and engulfs it kills it right so you you eject the amoloid it goes in it kills the virus and then there but it's it's outside now so now we have to get you into deep sleep at night which is why we sleep in fact before antibiotics in penicillin we were sleeping 11 hours a night

“so it'd be able to clear it all out right that's how you do it so then you've got”

tau protein our tau protein lives in the in the axon as I mentioned and if that builds up it actually causes the collapse of that tree trunk sure so then the question is well how do we stop it from being ejected why would it like how do we like it makes sense right

that'll solve it but why does it get ejected well because it's it's an antimicrobial peptide it actually gets released every time you activate your innate immune system every time you get stressed

“remember the brain doesn't know the difference between you getting hit by a car or you just”

receiving a text from an x it depends on your emotional security at that time if you get stressed and you release all of this cortisol it signals to your brain that you are under attack you're running away from a lion massive amount of cortisol the stress hormone gets released so your brain is like I'm under attack let's release an allude to protect our brain cells we're going to influx of inflammatory cytokines these these neurotoxic prote these neurotoxic cytokines

that go into the brain just like inflammation in your body but inflammation in your brain your inflammation if your brain senses it's got inflammation it starts to release amoloid to protect you

and when it's first released when amoloid is first released it's it's it's not harmful it's soft

it's a monomer it turns in it turns into this a lot these different fibros and then it actually comes together that's when it becomes toxic so amoloid's not the demon and yet pharmaceutical companies know this and yet they're still spending money giving you a medication to clear the amoloid when they should be spending their money figuring out how do we get people to stress less sleep interventions natural things to help people in their daily lives to prevent this from happening

why aren't they doing it just because of the business well there's no money in it you can't make money on an exercise intervention because it's free you can't make money really on a sleep intervention because it's free you can make money on a monoclonal antibody which is the IV drug

“lecanumab and denonumab that's what they are if you ever hear the word map on the end of a”

pharmaceutical it's a monoclonal antibody so these are used to go in and clear the amoloid but that's not the problem so there's another phenomenon that I want to bring you know shed light on which I think it's really really fascinating we have something in our brain called cognitive reserve

I mentioned to you 87 billion neurons by the way every neuron has around 15,000 connections

do the math on that 15,000 times 87 billion that is your neural network and it's firing right so the leaves again when they communicate with one another that's a connection yeah 15,000 per neuron those connections are your cognitive reserve right so we want to keep it in reserve and the reason why you can have a head full of amoloid at the end of your life but preserve your cognitive functions comes down to your cognitive reserve your cognitive reserve is built

through everything that you do right when you go for a run you build new connections in your brain

when you see something new for the very first time you build new connections this is why a baby's

brain is formulating so rapidly because everything is new to them sound colour anything light buildings everything imagine seeing something for the very first time your brain has to build a connection so this happens throughout our life and you can keep building cognitive reserve it's really beautiful but what happens is we stop doing it because we get older and we stop exercising actually a huge risk factor for Alzheimer's disease and all caused dementia is retirement

because you stop interacting socially you stop using your brain you stop providing it stimulus therefore it's not creating your connections and also those connections that were preserved the ones for mathematical reasoning or social connection if you stop using those connections die off I'd be that's interesting because you would think it'd be less stress after retirement but that's not what your brain is your brain is it needs stimulus just I mean you

would think that is well like oh why would our muscles deteriorate if we just have less stress well

“you have to use them and you have to provide it stimulus from to grow and adapt that's actually”

evolution right adaptability so you provide a strong stimulus and it grows and it adapts so

day to day that's going to be effortful right yes exercise but how about reading I don't know if

you agree with me on this I'm you're amazing sure you've got so many books and I'm an avid reader

I think we have a literacy problem in the US right now and like a lot of people are finding it difficult to articulate words to articulate their thoughts and to even read because they don't have to because we've got AI now or we've got videos on YouTube you know growing up we I didn't have the internet I know it's kind of makes me feel all but every time I needed to study so my father would say get the encyclopedia so you'd have to build those connections we're losing those

“so seeing you know new cultural things and if you want to age somebody fast get them talking”

to the same people every day get them doing the same things not challenging their brain living in a secluded form talking to the same person every day and not seeing new things if you want to grow your brain and have an enriched environment travel travel somewhere because you see

something new that your brain's never seen before and every time you see something new

your brain creates a new connection and you add to that cognitive reserve bank let me tell you you want that bank you want it there because you never know what's coming your way you don't know you know you have a tragic accident where you can be accustomed the head you don't know if you're going to get a virus that will engulf your brain you want to be able to have so much reserve there to overcome any insult that it takes what is the what is a person with all

“time is experiencing I think I think pretty much everybody knows what it is from the outside”

but what is what is the person actually experiencing is it stressful for them do they do yeah how did how does it how is it at the core loss of sense of self what is yourself it's your it is your cognition so they're losing sense of look you've got in some aspects loss of spatial awareness right where they can come closer towards you I've noticed this you know with my father you know he had his stroke and a stroke obviously causes deterioration a certain part of the

brain you lose the cognitive faculties around there I've noticed his loss spatial awareness and you see him sitting close to you and it's so interesting you know he sits so close to my mother now on the count he doesn't realize where he is in space and time you can forget obviously you can figure certain things like walking into a room yes but to a larger extent you can be driving which happened to my father as well which is I don't think he should have been driving he was

cleared from the doctor because his eyesight was fine cognitive faculties were fine he was driving he forgot to hit the break right he went straight through a traffic like car tumble down he was left upside down and he had no idea what happened in that moment and he was he's miraculously because of of God I believe he was fine he came out without a scratch but the car was torn apart

I asked him like what what happened he's brain didn't relay in that moment and that split second

red light stop which he knows but just didn't happen in that moment so people are feeling you know they don't want to be so you know you can get auditory dysfunction actually the American Academy of Neurology actually put down mild hearing loss as a symptom of cognitive impairment so you get mild hearing loss and it is now a risk factor for Alzheimer's disease and dementia why do you think that is that's because I told you every brain cell in the brain needs to be utilized

it needs to be or it starts to think that hey she's not using me I'm going to I'm just going to die because she doesn't need me anymore to preserve my energy your ears are here right and your ears are connected to the cells in your brain which is in the in the temporal lobes of the brain remember that's where deep in the temporal lobes that's where the hippocampus lives if you're not using

“the cells around here because when you hear sounds you need to process those sounds in your”

brains you need to use this part of the brain to process sounds and if that's becoming dysfunction because you can't hear anymore then those cells in the temporal lobes start to die which is why with the military I spoke at the inaugural military convention on TBI's and sounds people think the TBI's it's just the hits to their head it's no it's the sounds the massive explosions

hearing aids are phenomenal because they can help you preserve your cognitive functions

if you start to you know lose a sense of sound then that can deteriorate your brain the back part of our brain the occipital cortex we don't see without eyes we see without brain you've got your eyeball there the retina then you've got the optic nerve that comes out of the literally from your eyeball goes into the brain and the signals travel down here to the back of the brain where you make sense of your you've got a black hat on the only

reason I know is because this part of my brain is functioning it tells me what the image is

and then it relays it back to the frontal cortex that's the executive processing part of

the brain that gives you the idea that hey that is a black hat that you are wearing that becomes slower over time right if you've got Alzheimer's disease or if you've got mild cognitive impairment that rate and that speed becomes slower so you'll see something happening but it takes your long time to process it okay this is why some people who have got a lot of cognitive overload when they're driving and they're trying to figure out where they're going you just need your eyes but

they're like turn the music down I need to see what I'm going or they aware I mean how lot of them get angry of course they're angry they're frustrated because they don't know what's happening to them they're experiencing a loss of their faculties and I think I know for myself and I'm in my 30s right when things become I'm not as sharp as I was in my 20 when I was 25

“oh my god you should have seen me like I was I was able to do so much with little sleep”

right now I need my 7 hours 7 and a half hours and I don't I'm not myself things are becoming slower for my father especially he gets very frustrated and his frustration turns to anger when he has to do something that is a bit mathematically challenging so he took care of everything in our house and now my mother does when it comes to bills and you know their properties and investments and my mother has to take care of all that because my dad's simply just

he looks at it and it's he just cannot make out what to do and it frustrates him and he's spoken to me about and he very much frustrates him to the point that that's when you start to lose if you start to question who am I in this world damn and depending on where look our son is these other mentioned it starts in the hippocampus and it starts to go out into the temporal lobes and then the the frontal part of

“the brain remember you're frontal lobe it's the biggest part of the brain it has the most amount”

of neurons it that's where our executive functions live in the pre frontal cortex I kind of think of the pre frontal cortex as the the federal government right it's making all the decisions and that starts to deteriorate and that because it's so got the most populated amount of neurons those start to you know become dysfunctional and that's when we start to you know our thinking and our intellectual capability start to decline let's keep going if you're okay

I said to you that it takes around it's a it's a highly metabolic organ so how is it powered right so how are you on surviving it uses glucose as its primary fuel source right so glucose is its primary fuel source have you heard that you know in some aspects that our sinus disease is

“type three diabetes that's what they say right why is that well as we get older and actually it”

coes more in women so this is where we're going to be a bit gender specific why are 70% of all

Alzheimer's disease cases female right why is that well a because the first the you know the biggest

risk factor of Alzheimer's disease is age right as you get older you've got an increased risk of getting the disease the second biggest risk factor is being a woman really yes the second biggest risk factor is being female and that is because of two reasons a on average women live around four point five to five years longer than men so it increases their age so they've just got a greater susceptibility of getting the disease the second one is because women go through the hormonal transition

estrogen and progesterone and you know what this is called this is called menopause okay

“when you get the complete cessation of our primary hormone which is estrogen right so just with”

the amyloid cascade hypothesis we used to think that estrogen was just a reproductive hormone that's all we thought it was women you know start you know stop to the you know they stop producing estrogen that means they can't produce children anymore that was it but it's only been in the last 10 15 years that we now know that estrogen is a neuroendocrine hormone meaning that it is a hormone that we need for our brain cells to survive now you are a male you have estrogen too

and your brain is more protected because you go through your own type of menopause it's called antropause but for women it's this steep steep collapse okay so at age 45 right this is what happens the decline of our hormones start to go down like this for men it goes down really really slowly so you can maintain your estrogen and your testosterone you have estrogen too believe it or not what happens with testosterone in the brain is testosterone aromatizes into estrogen so you have

that protective barrier in your brain of estrogen throughout your life whereas women downforce we've lost our estrogen right we can help that with hormone replacement therapy but why is estrogen

“so important well on ourselves we have receptors right for estrogen imagine a receptor like a”

canaloc that's the receptor sitting on the cell body this is estrogen estrogen flirting along a gets in and then it can get into the brain cell and what estrogen does is it helps with neural inflammation so it detects the case she's got inflammation in her brain it brings it down it also helps shuttle glucose into the cell so if I don't have estrogen in my brain anymore where's the glucose going it can't get into the cell so therefore I've got two problems I've got a build up of glucose

in the brain because it's not getting into the cell it's not getting utilized right just like the glucose in your bloodstreaming your body you become insulin resistant so higher risk for diabetes insulin resistance in the brain so it starts to deteriorate the blood vessels of the brain because it's just floating around in there it shouldn't be there and B that means the cell doesn't have energy it doesn't have its fuel source because it's not being able to get

“shuddled in so what does it do well the brain cell in that state that's what's causing”

the brain fog in the menopausal women with her brain fog is deteriorating the phalamus which is where

our temperature control mechanism is so this is why 60 to 70 percent of all women experience

hot flashes during the menopausal transition because their hyperthalamus doesn't have the estrogen anymore so it's not supporting the hyperthalamus anymore so the the thermoregulatory system in your brain doesn't know what it's doing so it's making you go really really hot and then it's making you go really really cold and that's a hot flash and that's keeping women up at night not allowing them to get into deep sleep not allowing them to clear out the plaques so we've got so many

problems and that was another forward study back in two in the early 2000s the women's health initiative by far the most fraudulent study in all of medicine and it it stopped and wronged millions upon millions of women out of taking hormone replacement therapy millions and so now we're suffering right we've got all these baby learners my mother is one of them she's 72 years old and she's got

her cognitive faculties intact she's fine there but she was scared out like she heard her doctor never

told her to take you know 20 years ago to take hormone replacement therapy because this study went out there and said that hormone replacement therapy increases your risk of breast cancer that's it no no that has been retracted we now know that hormone replacement therapy is safe they used a different type of of estrogen back then when they were testing an on women there's many things wrong with the study A they were putting conjugated estrogen which is they took

the estrogen from the u-rine of female man so horses horse u-rine estrogen and so it's a synthetic form of estrogen they were putting it into these women there's women on average around 63 years old

risk of dementia so what we have now is we have a safer option for women it's biol identical

hormones so you can take a you know a hormone patch an estrogen patch you put on your your body

“and you replace that I believe I'm not on HRT yet but I will in my 40s basically we have a”

window of opportunity so women must get on their hormone replacement therapy between the ages of around 42 45 and 52 when you still have circulating estrogen in your body for it to go in and mimic that hormone and it becomes biol identical so you have that you have now a safe guide is called the window of opportunity so women need to start hormone placement in their 40s correct so generally you want to get on it when you're in the parry menopause stage which again

just like mild cognitive impairment parry menopause happens 10 years prior to the onset of menopause menopause is just one day right it's when you have been 12 months without your menstrual

cycle so if you reach that 3605 then you haven't had a period that is the first day of menopause

which generally happens at around 52 right so women can get into parry menopause in there you know

“at 42 at 40 of varies and that's when you need to go to the doctor and discuss your symptoms”

and it can help you it can help you stay off dementia and Alzheimer's disease and it can help you with your symptoms which is the biggest thing affecting these women is there any data that shows how what percentage it adores dementia Alzheimer's so we haven't got the research yet okay the research is underway and actually this is a huge controversial debate amongst academics right now because we can't solely say hormone replacement therapy prevents dementia we can't say that

but what we can say is we know for sure that it helps with the symptoms involved in the risk factors of dementia meaning if a woman's going through parry menopause and she's experiencing hot flashes that means she's getting up at night she's frustrated she's hot she's sweating right that's keeping her up at night that's a to sleep deprivation is a risk factor for Alzheimer's disease if I can correct that inner woman then that's going to help her stay off Alzheimer's disease right

what is another risk factor well diabetes osteoporosis huge risk factor as we get older a lot of women who are in menopause have osteoporosis because we have estrogen receptors on our bones when we lose those then we stop the formation of our brains growing and they start to deteriorate what happens if we get osteoporosis well our bone actually communicates with our brain

first and foremost but a woman if she experiences a fall in her 60s or 70s it's a steady decline to death

after that sure yeah so there's so many things so I like to think of home and replacement therapy it's not your bail and end all but it's going to help you go to the gym it's going to help you lift weights estrogen is anabolic to muscle so it's going to help you build more muscle it's going to help you with your mood swings it's going to help you with your hot flashes so

“that's that's what it that's what it's there to do it's to help your symptoms so you can then do the”

things that you're meant to do like go to the gym sleep eight well so then you can have a better healthy brain okay okay fine if we take a quick break yes perfect aging is inevitable and if you're anything like me you feel it a little more every year sore knees tight joints recovery takes longer than it used to we can't stop the clock but we can take care of ourselves that's why I take bub's natural's collagen peptides

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all right Louisa we're back from the break which is kind of wrapped up women's hormone replacement therapy I wanted to go back just a little bit about what the what a person with all timers is actually experiencing and I can't we kind of talked about the beginning of it but I have I don't my wife actually want to her really good friends her her father has it and they

sectioned off the house and did two different basically apartments and her dad she's completely gone

and you know my wife is astralic you know how do you how do you deal with this and she she says I don't even visit him anymore he's he's legitimate like she she can serve some dead it's just not

“and that's exactly remember at that stage you're that's it you don't know you don't even you don't”

you don't have control over anything it's you are not in control anymore when your it's your brain has now taken control because your brain has decided that it's time now to like decompose really because it's it's thinking well I am no longer like it's that the signals are all cut off so you are not in charge you're cognitive faculties that are responsible for you going to the toilet or you don't have control over those anymore it's another force and that force is the accumulation

of those amily parks and so what you'll notice though is a lot of patients who have got our Alzheimer's disease we're not talking about mild cognitive impairment anymore they kind of feel like they want to do this from the world a lot of them you'll see they start they stop to they stop going out and communicating with people and socializing and they become so secluded it's like they just want to stare at the wall I've had the daughter of somebody tell me that

their mother she noticed that she started sleeping facing the wall only she didn't want to see

“anybody's just wanted to face the wall and that's it that's what makes it so devastating so they're”

feeling lost they're feeling confused but they're waking up every day not themselves so it's it's not who they are and it's so devastating you know we think two thirds of our Alzheimer's disease

cases our female and then also a third our carers a third our what a carers so it's usually the

females who then end up taking care of a person with Alzheimer's disease I'll be at mother father husband whatever it is so you've got enormous pressure place and Emma Willis speaks about this the wife of Bruce Willis like caregivers enormous financial burden and seeing a loved one forget who you are so it's actually hard on both parties it's hard on the person itself

“you have to think this person who has Alzheimer's disease they don't know if they've eaten”

sometimes a lot of these people starve as well they don't know if they've eaten they sometimes they forget to swallow they don't know if they've hit their head they don't know if they're feeling pain or not they don't know if they've been to the bathroom more often then not it's you know just the wedding themselves or something like that so they don't

your life does not function do they go in and out of it they can become lucid at times yeah and that's

“very unpredictable why does that happen that just happens well we we don't know you know you can”

become a it's just a small moment in time where you can be laying there on your bed and you can recognize your wife or your child you can recognize them for a very short period of time there's a movie that was made and it was so beautiful I figure the actress is a name but it's

called still Alice and and basically it chronicles the woman who gets diagnosed with dementia

in her 40s and that's called early onset Alzheimer's disease that's the one that's predominantly genetic as I mentioned earlier when you do get those genes if it's pre-sonal the one pre-sonal to amelope precursor protein if you've got it you will get the early onset Alzheimer's disease in your 40s right but most of diseases occur due to late onset Alzheimer's disease which is the genetic which is the lifestyle ones so if you see her in this movie you can see the fast deterioration

“of who she is to death really and you should watch her because she starts to lose everything like”

first of all she she's driving and then out of nowhere she's looking at us like where am I driving to

what am I doing and that's the mild cognitive impairment stage but I was asked on to hurry of a CEO which is quite a funny question to me when he's after I explained it over a three-hour period what Alzheimer's disease was he said Steven said well what would you do if you got Alzheimer's disease and it's like sort of a question I don't I couldn't do anything in that moment I could not do anything nothing no no therapy would help me no amount of exercise would help me no amount of

sleep would help me my sleep would be completely disrupted I wouldn't know who I was I wouldn't know if I'm walking on the road I wouldn't know if I'm eating out of a garbage trash can I wouldn't know what I'm doing reason I was just I'm wondering you know is this is it harder on the family or the caretaker or is it harder on the person does the person even realize what's happening

“did I mean exactly and that's what's so devastating where they just staring off into space all the”

time and then they don't know they don't know just like this beautiful patient and I say came to me literally and I have seen and this is how I really started in this going on this journey of wanting to end this disease and focusing on women as well because I did have this one woman I was tasked with them I mean you're a physiologist so usually somebody who you'll see when you've had when maybe you've suspected of having MS or you've had a seizure and we assess the functionality

of your brain and I was tasked with heading up an entire mild cognitive impairment or Alzheimer's disease unit and I had to do that by scanning brains and I scanned thousands of brains and every time I would go to a meeting these you know by weekly meetings I'd say you know I'm giving a diagnosis of MCI to 90% of these patients but like a third of them are women why and every time

I asked why they would you know the attending would always say to me it's just what happens we can't

do anything about it's just they've got it you know genetics it could never give me an answer it was frustrating because one woman came in I tracked her over a five year period husband two kids came in addressing me by my name and over that period at the end of those five years she'd come to me and she'd say you my daughter and at that time I was troubled because I had built a relationship with her and her family you give the diagnosis of there's nothing we can do

and this was you know somewhat ten years ago we didn't know as much but then you're that the the sparse you've lost somebody it is like a death they are no longer there yeah when it comes to habits or anything that increases risk is there is there increased or there's with alcohol marijuana drugs certain medications what what what are some common things the people are doing that increased risk so there is the famous lens at study lens it is another

academic journal that came out with fourteen modifiable risk factors meaning that these are

that there's fourteen right so they include things such as first of all smoking right we all know

this if you smoke you increase your risk of all cause mortality we all know that hypertension so your blood pressure if that's high I told you we want to maintain blood pressure we want to maintain a hundred over one twenty over eighty as the gold standard I don't know do you measure your blood pressure everyone's in a while there's now actually continuous blood pressure cuffs so I'm going to buy one for my father because that um increase this is what caused

his stroke right so this is a really great and easy way I'm not invasive and inexpensive obesity

“one of the biggest risk risk factors of getting the Alzheimer's disease is obesity which I think”

now we've got a grip on because of glp ones which is what makes glp ones you know we're gov like ozempic and chasepatide which what makes them so phenomenal so these are good drugs oh yeah oh my god I am they are remarkable glp ones are absolutely remarkable and I think

you know when when when when we first founded as humans penicillin it was like this break through

moment then there was insulin which is also a peptide break through moment now we have you know we can help people with type one and type two diabetes now glp ones and I think it's definitely on par and I think it's going to be something that is going to eradicate diseases wow glp ones will eradicate diseases that in a hundred years I don't think what you you and I won't see them but I do believe in a hundred years people will be saying

people were obese you look we will be our nation we'll be in our society we'll be in in medical

textbooks and people won't recognize it I don't think people will know what Alzheimer's disease is

“either you think it will solve that eventually I think it's going to solve a big portion of it because”

we're now there's a huge evoke trial which tested due glp ones prevent dementia and it failed but it failed because of many reasons a we can't directly say that just take the glp wanting you going to lower your risk just like hormone replacement therapy it's doing other things a it's helping with insulin resistance and be it's helping with obesity see we're seeing a lot of patients who are they don't feel like they want to drink anymore so it's stopping alcoholism in fact I think

was it this year in 2024 alcohol sales have completely gone down have you seen that now there's I've heard the yeah which is phenomenal right because alcohol increases your risk of Alzheimer's disease so trazepetide these we're now getting read a true tide which is has got three hormones in it now

“trazepetize has two I think this is going to be even more remarkable so yes so obesity is a”

risk factor type two diabetes is another modifyable risk factor so you mentioned like what am I doing to increase my risk well drinking alcohol no amount of alcohol no amount I don't care what anybody says is good for the brain alcohol is actually diminishing the white matter of the brain so you know that that you know how I told you about the axon the tree trunk so that's part that's coated in this myelin sheath right and if you have a look on imaging it's called the white matter

of the brain the white matter of the brain is the myelin-eated neurons it's the tree trunks of the brain so when you drink alcohol and this was actually done in a UK bio bank study we drink alcohol even as moderate drinkers which is around seven drinks a week on neuro imaging when they took photos of their brain with an MRI they showed what we call white matter hyper intensive so in the white matter of the brain they've got these these deteriorated portions you're also affecting the

brain matter of the brain which is the cerebral cortex where the neurons cell bodies live so alcohol is detrimental for the brain okay so don't do that evidently like I said to you smoking social isolation is now becoming a huge huge run as well we're becoming why is that why is that well we're coming more isolated because we're obviously on our computers more but why is that well there was an 80 year long study done at Harvard which showed they wanted to track over an 80

who's aged their brain well it turned out that it comes down to the quality of your close relationships out of everything out of they accounted for every variable they counted for sleep nutrition exercise and it turns out that those who maintain good quality relationships showed better

science of brain aging than those who don't why well basically if you have somebody that you can

“lean on throughout your years this doesn't mean romantic partner doesn't mean you have to”

go and get married to preserve your brain right it means that if you can feel safety in another person that you trust that knows who you are it regulates you more regulates your nervous system better secondly if you have somebody that you can talk to who knows your life and that you can have deep conversations with also challenging conversations that's another human that you're interacting with remember every cell in your brain is getting utilized the way I'm looking at you right now your

facial features might be being able to pick up on everything you're different to obviously you look

different to somebody else so my neurons have to accommodate for that so having somebody by your side that you can talk to and this is why you know close friendships that take you know that take long long years to accumulate really matter is there any there any information on how many

“relationships you should be maintaining no but I mean it's very hard to maintain close relationships”

I've got a close group of friends and you know you're not just like acquaintances you you know and this is you know I've built my close friendships and I spend a lot at you invest a lot of

time in them because you have to and I've maintained my close and some of them are falled off and

yeah build new ones any other risk factors um well exercising probably the biggest one is lack of physical activity in fact in activity is now a disease state in activity and sedentary lifestyles is an actual disease are you serious yeah what is that disease called in activity set well it's called sedentary yeah sedentary lifestyle it's now classified as a disease when did that happen uh back in 2024 how many

people are suffering from that disease that's a choice it feels like a choice not a disease well you could say the same about type two diabetes it is a choice you could say the same on some pie no this is controversial because of you know GLP ones but obesity to some extent apart from you know different genetic risk factors could be somewhat a choice you do get a choice in everything you do uh which is the choice to get up and move so that actually is a really good segue to

what I focus most of my my academic research on in that exercise so if you want we can delve into that how many days do you have we got as long as we need um I do want to point out because I I just I mentioned women men have something else that's not often spoken about it's called mloey where 17% of men actually lose their y chromosome yeah and they lose it in the immune cells so you're obviously you know we have different genes x and y xx 17% of men

lose their y chromosome in their immune cells which actually is increasing their risk of getting dementia and different neurodegenerative diseases as a whole family and it hasn't been

“specified yet but my hypothesis you know I think about well why I'm men at an increased risk of a”

Parkinson's disease and be a myotrophic lateral sclerosis I don't know if you saw McSteamy from grazing out of me I forget his name in life he oh one of the leads in grazing out of me just passed away of ALS I think was two weeks ago which is very it's probably the most it is so scary shown to see in real life because it's so fast acting and deteriorating so I you can test for this you can test whether you're losing your x chromosome through a genetic test um

generally over the age of 15 so that's one thing that we didn't pick up it's called mloey okay so

A exercise is free B the only reason we call it exercise it wasn't called exercise

“200 years ago because people were running and doing things we have to now because of”

technology in the way we're living we've now formulated the word exercise right which doesn't mean which I tell my mother every day doesn't mean you walking around the house and getting the clothes off the line that's not exercise right exercise is structured programs where you are increasing your heart rate or moving your muscles or contracting

your muscles so first of all we'll we'll separate into three you've got the aerobic exercise

and the the the fast pacifier to maxis exercise you've got resistance training or strength training and then you've got what I call neuro athletics or neuro cognitive training the relationship between aerobic exercise and brain health was the first one to ever be discovered marion diamond back in 1960 well 1961 basically she got two sets of rats right two sets of mice and one we're put on a protocol of wheel running so she got these mice

running on wheels and she got them in what she called an enriched environment she was the first female neuroscientors by the way enriched environment so a really nice cage lots for them to do and with other people as well what other mice over six months of wheel running every single day what she found was that their brains grew she's like why were their brains growing and not so they were they were growing new new brain cells in their brain

and she figured out that the mechanism was every time they were running and their blood was flowing through their body they were releasing a hormone called bdnf brain derived neurotrophic factor and it turns out that this is a growth factor for the brain so when it goes into the brain of these mice it grows the brain right what she found was with the other mice who didn't do anything obviously they weren't in an enriched environment they were in a depressive environment

actually their brains shrunk especially the hippocampus so that was the start that's where we

first knew that exercise is good for the brain when replicated on humans it works the same so

when we exercise we get this massive bolus okay massive release of bdnf it goes into the brain and it helps our brain function better but it doesn't help us growing new brain cells in fact we can't as humans growing new brain cells as called adult neurogenesis it doesn't exist which is sad because if you've taken a huge hit to the head of TBI and you kill off brain cells you can't revive those like my dad when he had a stroke killed off certain neurons in the brain

they can't grow back but what we can do is we can grow new neurons in the hippocampus

“isn't that beautiful because remember the hippocampus is the first structure to go during our”

Simon's disease so if we exercise now this beautiful study which is one of my first most favorite

studies in 2011 erics and at all basically what they found was if you exercise for 30 minutes a day aerobic exercise you can grow the hippocampus by 2% the volume of the hippocampus you can grow it just by 30 minutes of exercise a day not just that 30 minutes of exercise a day you know what else it does it down regulates 13 types of cancer no kidding yeah there's now it's so prominent that there is now a new field in research or in medicine called exercise oncology

I've done a whole episode on it it's one of my best performing episodes which showed that through exercise interventions you can mitigate your risk of tumour cell growth no shit yeah most prominently breast cancer colorectal cancer wow yeah that's prostate cancer those are temporary prostate cancer just from 30 minutes of exercise so exercising for these long period of time using the aerobic system gets the massive release

“of bdnf and that's what's helping the brain now we didn't stop there that was the first”

ever studies then they moved on to what does the high intensity exercise do you know that one that I don't know what your exercise regime looks like but um the v2 max exercise where you're going so hard you feel like you're going to vomit in when I was a triathlete we would call them spew sessions I don't know if you've ever do though do these not anymore well you should okay spew sessions right so it's when you're going hard out you're in that zone five cardiac zone right

well a to go to that effort you're using the anaerobic system right so when we're in the aerobic

system doing the long exercise bags where you can last for 30 to 60 minutes of running you're producing energy in something called the mitochondria okay the mitochondria is the energy power

“house of the cell so we're in there it produces energy for us and that's how we get our energy to run”

but when we're going so hard out at 90% of our maximum heart rate it's it's the mitochondria can't produce that energy in that fast time so when it does when we produce the energy it happens outside of the mitochondria a byproduct of that okay during the the byproduct of producing glycolysis is lactate and lactate produced in that moment is a fuel source for your brain so the lactate

it's it's a it's a myocone so basically it comes out of the cell and it goes into the brain and that's

what can produce better brain energy it can help neurons that are dying survive better it can help with brain energy metabolism so it helps your brain produce more energy and utilize energy better it's just such a phenomenal phenomenal fuel source for your brain right and this is where most of the

“studies are done on cancer in fact what we find in the cancer research and exercise research is”

exercising at that intensity right what happens is you get this shunting of blood right imagine the tubes like the highway system like your your blood is pumping boom boom boom boom boom boom and in that moment when it's pumping it's taking with it and clearing out something called circulating tumour cells right so when you have stage one cancer it's local okay it's a it's a growth it's a tumour that's formed somewhere in your body right let's just say prostate stage one

meaning it hasn't metastasized but the way tumour's work is the tumour cells off that one tumour break off and they they go through the bloodstream and they think work and I lodge myself again and if it does if enough tumour cells break off and then they form another little family that's metastasized now you're moving into stage two and stage three exercise at that zone five

“is clearing out those circulating tumour cells and that's how it's down regulating tumour cell”

growth wow yes and a study was done on this in the journal cell which showed the effects of this of inhibiting prostate cancer in then so that was pretty interesting too it's good to know

so it's doing a whole host of things where my area of research is really taking place I first

authored a paper that was printed in the journal of aging was I wanted to look at what are the effects of resistance training on the brain and turns out that there's far more effects of resistance training on the brain than these two categories first of all when we when we you know lift a lift a dumbbell right and where we're shortening our muscles we're contracting our muscles what happens is we produce and shoot out something called myocines these myocines live in the skeletal

skeletal muscles right they they live in the cells of your skeletal muscles they just live there and when you squeeze them hard enough like literally under tension they get released and when they get released they go into the bloodstream and they travel and we've got receptors just like the the hormone receptors of estrogen we've got receptors all over our organs our heart our liver our pancreas and our brain and when these myocines get released they do so many

different things they go in like instructions I call them care packages they're going to different cells and they help the cell perform better so cells are they're really phenomenal right whether at the DNA level whether just in the cell itself the cytoplasm they've got instructions on how to do things how to keep you from dying pretty much or how to you know survive like how to you know how your cell survives when those instructions like when the mitochondria becomes

dysfunctional that's really at the root cause of all diseases but we can fix this mitochondria right by sending instructions to fix itself right it's called autophagy we can grow new mitochondria or we can just correct the bad ones right and we can do that from these myocines so when the myocines go into the brain they're helping the brain do better things they're helping the synapses

it's called synaptogenesis um they grow new neurons in the hippocampus they help you grow your different areas of your brain grow and proliferate they work together as a camp there's like 100 different myocines they work together as a camp to help each other express themselves they help with immunity they help with the clearing out of amoloid beta they're doing so many different things for your brain and your organs that I go to tell you pharmaceutical companies are trying to replicate

these myocines they're trying to replicate them in pharmaceutical forms to make them injectable drugs

and they can't do it really how long have they been working on that years ever since we first

found out about myocines like back in like you know the early 2000s they don't figure it out I hope not that means we just got literally just gonna sit there for the rest of our lives and inject ourselves right I mean look this whole I don't even want to get into peptides but look

“I think in five years everyone's going to be using peptides really why I have because”

where people are becoming you know the gray market the black market is in full trade like people are buying these black market which I it's so dangerous by the way peptides right a peptide is an amino acid amoloid beta is a peptide right and I think in theory they can do well we've seen them

you know in my studies but not one human randomized control child has ever been done on peptides

which is why it makes it so dangerous we don't know what the safety and efficacy is of peptides yet but I do say that they will start funding it because of who's currently in charge and yeah I think that you know we'll start to see human studies in five to ten years and that's what's going to happen so you're not you are not a fan of peptides I am not a fan I went out really public with this because one of the things that BPC157 does that's the most prominent

peptide right now body protection compound 157 what it does is it's it's meant to help with cartilage health and recovery that's a lot of people are taking it what we don't know yet is it's doing this by inducing vascularization meaning that it's helping you around the cells of injury it's helping you form you blood vessels when you form you blood vessels what happens you get oxygen in nutrients it's great right better healing but it can't detect whether it's causing vascularization

on a cancer cell and what a cancer what how does cancer survive and grow and proliferate put proliferate it forms blood vessels to feed itself cancer cells are so hungry when they form a tumour site they say okay great now any blood vessels to survive so they form its own little blood

“vessel supply and that's what grows and that's what metastasize and because they're like yes they”

become so greedy and so hungry these tumour cells they go out and metastasize all over your body you have no control over that right whether it goes to your brain or spinal cord you don't know so why would I accelerate that because we can't test yet whether you've got stage one cancer we could all be walking around right now with it it's just too small to detect on neuro imaging these imaging things they don't even detect it they can't detect it yet no

I mean look on some cancers yes look prostate cancer yes we can detect this is you know color rectal cancer yes this is why you know everyone should be getting screened and doing colonoscopies because around 95 99% of all color rectal cancers exist from the polyps that are built up but you can get rid of those this is why everyone should be getting screened and doing the colonoscopies and endoscopies but you know breast cancer I believe so but I'm talking like

you know pancreatic cancer you don't know whether you've got it until stage four and then

“it's you're done that's what took my grandmother that's what took my aunt overarian cancer you”

don't know glier blister I'm a forget about it so you know why would you I mean a lot of people are taking peptides and not knowing the harmful risk I took them BPC157 I believe that's what it was everyone's on on something called the Wolverine stack which is TB 500 and BPC157 there's Milana tan and then there's these secretagogs which some more alone if I'm on my role and I

and everyone's taking them but my question is first one I don't know if you know this but it failed

that failed it's trial you do phase one phase two phase three it failed when they found out how dangerous it was so the FDA cut it completely they said this is two dangerous to move forward in human studies

and get a prescription for BPC157 so I don't know where you got it from I'm scared because when you get it on a gray market or scarily on a black market let's just say you get on the gray market

the gray market means that it's not FDA approved but it comes with a form that basically says you

know this is what's in it you don't know what's in it it could the you don't know what you're injecting and you're drifting it systemically GLP ones are peptides but they've passed phase three clinical trials the FDA approved you get a script they're not compounded meaning that you know if you go and get it from we'll go views it bound like they are you know they're safe the safety and efficacy they have passed with flying colors how do you know that when you're using BPC157

that you are not inducing vascularization of a trumosal you know and you won't know sure so that's my problem now I got a lot you know I put this out on social meaning I got you know

even our Andrew human and message name I'm sorry like I I would you know there's another one

that's great for the skin copper GCU I'm not even sure what it is I'm into anything that's going to slow me the aging process right you know I spent thousands on my skincare products for God's sake if I thought these were safe for me and my mother and my future children I've everyone get I'd be telling my mom every day get you know do it of course I would right but I can't take that risk now if you could go to the doctor and get cleared and the doctor can say hey listen

we have scanned you we now have technology to pick up you have not one cancer cell inside you that is going to grow and proliferate then yeah and these are past clinical trials and this

safe thing yeah take your BPC157 if not to put an ice pack on like why are you taking it

why are you asking me I'm asking you yeah shoulders and what happened didn't you have gotten a little bit better but yeah and look it could be placebo or it could well and truly have down-regulated inflammation and helped the healing process this is why you injected

“at the site you probably injected it into your then that's how what I was on or I took it wrong”

yes but okay I'm not sure then what you were on I'm usually what happens if you've if you've you've got an injury usually injected at the site you don't have to but a lot of people do they like I can but a shoulder injury I'll inject it here because it goes in systemically and it does a number of different things but one of them is the the formation of the vasculature so it helps the healing process around that site what did humanment text you about he believed that I I

got something wrong which was in one study and I've put this out on social media it's funny when you do you know a one hour long episode and the thing that gets clipped there needs more nuanced right and what got clipped was I mentioned that in a phase two clinical trial I don't correct me if I'm wrong but it maybe it was Milano 10 it was one of the one of the peptides it caused

“death in one person and I stated that but I think when I got clipped it said that you know I was”

referring to every you know BPC 157 which I wasn't you look at the full clip on YouTube but you know he he wanted to correct me and I I re-corrected him and said well I didn't say that and because I think he's a proponent of of peptides I'm not sure if he well that's where I got my doctor from what's the recommendation from Andrew yeah which I love that doctor I love that doctor no look he he he's phenomenal I we've known each other for so long

and I think he he sits on the same bandwagon as me I think he believes that it's going to be a big thing in the next five to 10 years um I know he knows that there are no human randomized controlled trials that have been done outside of GLP ones and insulin which is another caveat people were telling me GLP ones are peptides I know that I'm not talking about those I'm talking about the ones that you buy on the grey market and secondly I wouldn't even you know I I don't even buy my

supplements on the grey market I make sure that my supplements which I know when it doesn't pose the risk that a systemic injection does I don't even buy my supplements on the grey market

“that's how like like adamant I am on safety and efficacy”

where do you buy your supplements? well I make sure that I'm buying it from a reputable company

that don't contain contaminants like I go through I look at their safety scores to make sure that they're not full of lead and full of gunk and filled with things that I don't want to be putting in my body in saying that I'm sounding so much unfarmaco centric meaning like I'm not against pharmaceuticals meaning you know I don't live my life like you know in an

“organic you know way like that no I think that there are certain things in life that you need to”

realize like what's safe and what's not you're not anti-vaccine that that's what you're saying I'm not anti-vaccine no and I can tell you why sure you know why why why am I not anti-vaccine um because they I mean I don't know my dad's a pharmaceutical oh good so because they save lives and they have eradicated diseases I want to put that out there so loud because we are here because polio doesn't exist anymore smallpox doesn't exist anymore

because of vaccines a reason why I'm I'm really upset with the decision of the current administration when they decided to eradicate certain vaccines from the vaccine schedule right

flu vaccine or basically for children they took around you know which is which is really scary

“by the way some of the vaccines you know that they've taken off the schedule”

could be very scary and detrimental I mean vaccine scare me they do especially you know I've I've uh two younglings and and the amount of vaccines that they want to give them when they have an appointment it's like I don't think we need to do six and the next five minutes or but I don't think people understand oh I get that I get that completely and I'm not also pro vaccines if you don't need them I supported the initial roll out of the

COVID vaccine schedule the initial roll because we saw that it lowered hospitalizations and death

what I didn't support is the second and the third and the fourth vaccines I didn't support that so

that's me not being pro vax or anti-adjustance support that because we didn't see that it made

“any meaningful difference especially you know keeping ten-year-old kids inside I didn't see this”

you know I didn't see that to be effective my problem is in in education now I'll tell you something the largest studies ever done I'm talking in Wales I've got a huge study I'm talking millions of people a huge study out of Wales Australia and the US for the shingles vaccine has showed that if you receive the shingles vaccine after the age of 50 you lower your risk of all cause dementia and Alzheimer's disease by 50 percent the shingles vaccine can reduce your risk

of getting Alzheimer's disease by 50 percent and that is even more pronounced in women so why are we telling you to stop getting vaccines do you want do you know what shingles is no you can't disease right you get chickenpox as a as a young kid right you end up in Russia you get chickenpox

that never leaves your body it goes and it lies dormant in the spinal cord in the dorsal root

ganglia we call it which is in the spinal cord under times of high stress and lower immunity usually in your 50s and above when you get stress it reactivates basically the chickenpox virus that lives in the spinal cord gets woken up it was dormant now it's woken up and what happens is it travels and depending on where it's asleep in terms of a nerve root it travels up your spinal cord and we've got things called dermatones right so if it traveled up this nerve root here you

would see that the the the rash the skin rash comes in the form of the of the dermatones so it won't just be a skin rash although your arm it causes these painful source in that that spinal cord our nerve root so now you've got this virus in the spinal cord and what happens and it goes up into the brain and what happens to viruses in the brain what did I teach you about amolid beta brain cells are like oh my god we're under attack it releases all this amolid

better to try and engulf it but in the process your increases the amolid beta plaques in your brain you know and you're causing a massive influx of neural inflammation increasing your risk of our

sinus disease but can prevent you like it this is a really painful rash why are we why do

not pick more people know about this right why are we saying no to the shingles vaccine people

“so scared of vaccine so that's my thing I think that education needs to come to the forefront”

at right now am RNA cancer vaccines I think that there's so much research that can be done in there these mRNA like vaccines like I don't think people understand that it's just you're actually injecting the virus a very small amount of it into the cell doesn't go into the DNA or anything the mRNA vaccines and it helps your body fight off the virus if it's super if it's going to come

and attack you that's all it's doing it's not people are under the impression that you get a vaccine

and it's causing lead build up or something like you don't know what's in the vaccine I don't trust them the same people at a scared of vaccines are the ones buying peptides on the gray market it's like make it make sense so as I mentioned earlier we have a huge literacy problem here

“because all you have to do is go and research and you will realize what the mechanism of action”

is of the vaccines and by the way the US and Australia have very strict vaccine protocols in terms of what they put into vaccine there's no lead in them I don't know what this thing is with lead I don't know who started that so that's my take on it I made my month my mom and dad went and got the shingles vaccine a few months ago what age what age do people be taking the shingles vaccine in their 50s in fact they they in the studies this this one out of Wales they

actually accounted for age and birth date so yeah you don't you don't need to be getting it before then so probably the at 50 yeah 50 if I've gone see your doctor and ask for the shingles vaccine I asked my mother I said did I ever have chickenpox because I don't remember it as a kid

“she doesn't remember it either so so if you didn't have chickenpox do you need to do”

I could still get it so you know I know I've got a friend a girlfriend who's got a two-year-old and she got chickenpox because he got chickenpox yeah so that's my that's my take on vaccines and I I just urge everybody to read a little bit more and become a bit more educated and I think people just get you know the covid covid just really fucked everything oh yeah you know people don't know where to look I don't know where to look no one knows where to look you're

to bunch of you guys I always ask about vaccines but you open your every time I say the word vaccine

did you know that Australia was the first country to eradicate HPV so because of the vaccine cervical cancer I didn't know that yes as of last year 20 25 we are now the first nation to have eliminated cervical cancer why wow because of the vaccine I mean that's phenomenal when you go against the HPV vaccine you go against women like why are we what are we what are we scared of I I would love to know I'd love to hold a press conference what are we scared of is it

because the very person that is you know HHS secretary the very person who we are supposed to trust and look to is actually he's confused himself I don't know if you know this but he went on back in the early 2000s to say that I believe in vaccines or my kids are vaccinated are we talking about RFK yeah well I mean RFK also just came out and supported a immunity what do they call immunity for pesticides for pesticide companies why how the fuck is that making America healthy again

and do you know the number one cause of Parkinson's disease I'm gonna guess it's pesticides are quite found in dry it's part of what is found on our crops and on our fruit great yeah and another triamethyl something it's another chemical ingredient that is found in dry cleaning products these this is why they call dry cleaning products yeah so all dry cleaners should be shut down if they use if they use this try it's try method if you just type that into Google I figured it's

called but this is what is causing Parkinson's disease but we're getting off track here but yeah so this is good stuff because I use a lot of dry cleaning so yeah shut it down all right

then fast forward like 10 years he went on to say vaccines I don't trust them there full of

lead and you shouldn't be taking them and he seems so confused in fact in a press conference he actually went on air to say to the American people do not trust your doctor take your health into your own hands a work in a hospital if we let patients take their health into their own hands I'm talking to very patients that don't even know where their neck is or where their knees are would be in a lot more trouble than what we are now you're it's like saying it's like getting on

“a flight and asking the passengers saying to the passengers don't trust your pilot you must take”

this flight into your own hands no wonder everybody's scared of vaccines no wonder we are confused when the very person we should be turning to for our health advice is confused himself I mean even the what back to their immunity thing I mean we just did a big episode on glyphosate which is you know the main chemical that they've are giving immunity to yeah yeah and Iowa has the highest concentration of glyphosate in the country and Iowa also has the highest

rate of cancer in the country so I don't know why they would give immunity to all these pesticide companies I mean that right there is pretty good fucking indication that the shit's not good for us but then they called a day what do they say it was a national security concern yeah but then I looked at a six hundred and something thousand six hundred and I think it was six hundred and eighteen thousand people die a cancer was of twenty twenty twenty twenty twenty twenty four twenty

twenty five yeah and we're calling the fentanyl crisis a national security concern and the cancer rate is six time over six times that of the fentanyl crisis so how is cancer not a national security concern you know what it reminds me of the saga the Tylenol saga with pregnant women or even the vaccines and autism there is not one one Coral and one reported the case of the vaccine causing autism not one where did it come from fabricated numbers but

they can't because there's no numbers to prove it so feel like the administration are just waking up and they're like oh what should we pick on today let's just let's just put our blind folds on any many many more autism okay what we're going to just pick on autism today because that's how we feel and let's just say that vaccines call autism and you know people don't want

“autism that's how I really feel like we are running science here and it's just it's scary even”

when it comes down to Tylenol how many poor pregnant women was scared out of taking Tylenol

during their pregnancy the first line of action in the event of the disease I remember my wife

was she doesn't want to take any time of course because they said that if you take Tylenol you increase your kids risk of getting autism and that's not true no the first line of defense for there is like and that I think they retracted that as well even at the secretary level even RFK came on and said sorry I'm a menomistic after like scaring the nation for a think like two months scared like like don't take Tylenol like all these imagine imagine right

a kind of imagine how it must feel not knowing anything about health because you're not in that feel there's many areas of life I know absolutely nothing about it I feel so blinded I can tell you how it feels yeah I'm so susceptible to you yeah when it comes to like make up I don't really know I I'm so susceptible to that I'll just buy anything because I don't know too much about it but

I kind of imagine how it must feel to know nothing about health to be a to be first time

mothering a child or even being pregnant for the first time to say don't take Tylenol it's going

“to increase the risk of autism imagine how you must feel so scared so lost so he retracted that”

so that's fine now take the Tylenol it's just for God's sake in the in the event of a fever in pregnancy the first line of action is Tylenol it's safe we got offline now the only other thing I would argue there is there seems to be this very big confusion around statins right statins are decrease your risk we've got two huge randomized controls that show that

Alzheimer's disease by upwards of 32% really yes let's go back to Henry's brain here

“just like cardiac do you know what atherosclerosis is no you know when you build up so you get”

cardiovascular disease which is the number one cause of death okay in the United States alone Alzheimer's disease and dementia is the number one cause of death in Australia and the number one cause of death among women in the UK in the US it's cardiovascular disease and then cancer so cardiovascular disease is just when the arteries are getting clogged up with plaque right and that's built up because you're cholesterol this is a very lame instead but your cholesterol builds up

in your bloodstream and it goes into the arteries and over time it gets lodged there and that's what can cause a heart attack the same thing's happening to your brain you get a build up of cholesterol in the brain and it causes a stroke or a hemorrhage right so why would we want a high cholesterol mainly LDL and APOB we don't so we can lower that risk by taking a cholesterol lowering medication like a statin for example the people who have got APOE4 the risk factor gene they are at an

increased risk because what APOE4 does is it helps transport cholesterol through the brain so if that becomes faulty which it does in APOE4 carries that means the cholesterol's can't get transported to the brain cells where we need them so they're going through the brain they're going into the arteries of the brain and that's where they're causing havoc so if you have APOE4 you've got an even better chance of lowering the risk if you take a statin and yet every time that's such and along with

“vaccines that's what I've seen is the most controversial pharmaceutical so as I put it up like”

I'll put up like a massive study that has just been public like amazing right people are just

traumatizing me for it saying that I'm getting paid by farmer what is the what is the scare about statins I I had this conversation with Peter at two right year or two ago yeah he's very pro he's on I think of PCSK 90 I think this I don't even know people saying you're increasing your risk of getting dementia which is crazy oh another scare is that it's causing muscle weakness I'm like great it doesn't I mean in a very small percentage of people it might

I don't know what the scare is but I know it's very controversial amongst that family of people do you know the medication that helps with acid reflux hard burn it's like improvise all or yeah is so that has supposedly has an increased risk for dementia I have to take that shit yeah after said also take a B12 shot are you doing B12 shots as well well she said that the reason that the for the increased risk and dementia with whatever that medication is called is that it

“creates a B12 deficiency yeah you should actually check as well on your blood panel if you've got”

if one of the biomarkers home assistant is raised as well but if you're taking a B shot it should be able to bring that down yeah look it's it's funny like that and you know you get you go

in for an you know you see you've got acid reflux the first immediate course of action is

just take this medication right have you heard that listarine you know the one that you drink is causing the same thing it's actually increasing blood pressure yeah it's the same mechanism basically and actually I would caution people against taking a listarine that I do believe okay yeah so mouthwash especially don't take that but for acid reflux I do believe it in some part yeah because I've also read about I'm not obviously because I'm not

I would go deep into I don't know too much about it but I did interview somebody who said the same thing that what are they saying that it's increasing blood pressure decreasing nitric oxide alright we're we spoke about exercise and then we were trying to say about pharmaceuticals and went into why I don't know you know more about politics than me I don't know why we're doing certain things in the way that we're doing it I don't think anybody knows any more

so a lot of confusion out there and a lot of different sectors of politics I want to talk to you about psychedelics I began psilocybin I mean it seems like there are a lot of

with TBI and the black spots and the scans are our full color I did it

yes you you I I read about your experience too you credit I began to you feeling better and mentally no booze no adder all no sleeping pills no none of that how did you administer on like that how long did it take you what was your protocol for I began or I went down to Mexico and took a couple of pills woke up and didn't want any

“that shit ever again and I still haven't the confusion comes in and this is why I think”

it's you know cousin you would ask us then why is this not getting approved everywhere why we still you know SSRI is going through the roof like prescription SSRI is anti-depressants are going

through the roof um a lot of midlife women who are experiencing these symptoms I mentioned

of parry menopause will go to their doctor who doesn't know anything about menopause and diagnosis and with the mental health disorder and give them an SSRI so then you think to yourself again why why can't we replace SSRIs with psychedelics is that where you're sitting out if it's done so well with you is that the question you have really I think I have a lot of questions I've been ever had that it could help with Alzheimer's dementia I've read that actually

I just I just connected somebody to the guy that I go to because his his mother father just got diagnosed with Parkinson's and they were asking if that can help with that size I said I have no idea let me just connect you and they send me a whole article one yeah how could potentially help with that I mean it's helping with with with with overcome addictions opioid addictions alcohol stimulants do you believe in microdosing I've done microdosing but to a smaller extent obviously you can't

microdose that one but people in microdosing silly side and yeah how do you feel sometimes if I do it I'll feel jittery at the very beginning of the day and then and then it'll kind of level out but I feel sharper yeah and I felt sharper after I took I have again so at the beginning of this I told you sometimes I'll forget my words or I'll get I won't be able to describe what I'm what I'm trying to do I'll read better and I noticed all these things

that like right after right after I did it I was like I'm not forgetting I'm not forgetting my keys I'm not forgetting words I'm not forgetting I'm not really forgetting anything I'm reading faster and better than I normally do my my my concern with this and by the way I'm so happy that you able to get out of the state that you were in because that's so scary to be in and to fact that you through this therapy which all you did was take some pills you said you didn't go through an actual like

“experience oh no I would I did an ex yes it was the whole yes that exists because what I believe”

is happening at a mechanistic level one thing is you know it's it's actually helping produce more bdnf what is that so you know bdnf the one that I said in the my studies from exercise okay massive balls every time you exercise and you're running you're producing all this bdnf right

brain derived neurotrophic factor so it's a neurotrupen so it basically helps the brain in many ways

bdnf is like fertilizer they call it and neuroscience fertilizer for the brain my problem is and I'm I'm not deep into psychedelic research but what I've heard and read and I was talking to a surgeon about this a few days ago who did the experience he said it enhances whatever state you're in when you're doing it so my my what I'm scared about when people do this is could they induce psychosis in that moment could they induce schizophrenia could they induce paranoia

I'm not sure I don't know if you've heard about anything like that if they could induce a mental state that they don't want to be in and could that mental state last a long time you mean well after the experience yeah I've heard that from anybody so the thing is what you're doing is you're enhancing the neural patterns right and this is why the experience matters you're

“not going to just go into an essential park and pop these pills right I don't know what your”

experience is that you went through right but I do know that you do need to go through an actual guided psychedelic experience rather than just doing it by yourself which is actually what poses the risk with the silly cyber usage like I think people are doing that unguided I don't

don't do it recreationally do it in a in a proper manner hmm how do you explain the

black spots on the brain well what's what's there what's where they what they want matter hyperintensity's I don't know I don't see that language if they had an MRI scan then it would have been the increased production of BDNF creating the and recovering the neural patterns that

“would last during whatever trauma that you went through remember that the mathematical equation”

from Warimma Colux is a neuron fires or it doesn't in order for a neuron to fire it needs a lot of energy and it needs a lot of help from nearby neurons so when it fires and it creates another neural pattern with another one you can do that synchronously with the help of BDNF so if you're going to if we produce let's just say 200% BDNF when we try 100% on top of your resting state when we're running I would dare say that the psychedelic experience is doing it by tenfold

so are you are you excited about so I'm very excited you are yeah I'm excited about it for the treatment I know that Dr Dave Rardon he's a psychiatrist he's doing it out of California doing a lot of the studies on psychedelics to help with major depression I think anybody in that stage if we

“can do anything outside of pharmaceuticals we're seeing that pharmaceutical interventions a yes SSRIs”

are necessary if somebody is suicidal of course but if we can get a better non-pharmicological way then I'm so excited about it I mean look we've even seen Charles Razon believes in your religious I interviewed him he's working on people with mild depression with major depression and he's seeing if he can replace an SSRI with sonotherapy and he did

with sonotherapy yeah he got these patients right and he basically split the two

split them up into two groups okay and he put one group he gave them all you know he put one group into the sonotherapy and gave them a sugar tablet so not an SSRI they didn't know that because it was an RCT randomized controlled child they thought they were still taking the SSRI he subjected them to really really hot soarners I think around 200 degrees or something like that seven days a week and he did this for a period of time and he found that over a over the the course of a

few months he was able to replace they felt they felt good there was no suicidal ideation all the depressive like symptoms eliminated just because of the heat so they found out that the heat shock proteins are actually having a natural therapeutic effect that can mimic the SSRIs so when I found that out I thought that was so interesting so he could actually eliminate the SSRIs from these patients but obviously you're not going to be doing sonotherapy's seven days

a week at this extreme heat and I think it was like eight hours a day as well it was a long

“period of time but there's a mechanism there so that's what got me excited about the potential mechanism”

of psychedelics do you think that there are any possibilities that it could be some type of a cure for or deterrent for Alzheimer's dementia yes I think not a cure I think could be a therapeutic agent I don't think there is no elixir there is no cure there is no cure for

Alzheimer's disease what you're basically saying is if we have a head full of amoloid and with

lost cognitive functions we don't know who we are could we take a pill I guess I'm in more of a preventative is a different story I think eventually we'll have a cocktail of of therapies that can be your prevention bucket for saving you from Alzheimer's disease it may even be can we can we inject lactate into our brains or into our you know peripherally which can go up to the blood burn barrier could we do that could it be the so I do think psychedelics will fall

under that that bucket mainly because if we can solve for the depression problem that's another risk factor if we can solve for that then we're eliminated a risk factor just like GLP ones if we eliminate obesity then instead of having 14 modifiable risk factors we go down to 13 will people with do people that have psychedelic experiences or therapy do they have less

of that oh I'm not sure I mean I don't even know the complete mechanism of action

“of what it would do you know if it would increase I don't think it increases maybe it does”

our parasympathetic activation which is the rest and digest which is what will probably slow down cortisol but I could probably like posture that if it is getting into the brain and it's helping neural networks and eliminate these depressive like symptoms then yeah it must also have something to do with the neuronal energy because we're seeing now that you can alleviate depressive like symptoms with creatine and that's because of the energy crisis that's happening in the brain

so people should be taking creatine yes how much creatine should they be taken we can segue into creatine if you like well over the last what 50 years from the Arnold Schwarzenegger days people have been taking five grams of creatine a day and what five grams does is it saturates the muscles

because the muscles are so hungry they get first dibs as soon as you have creatine they get first

dibs of it right saturates the muscles but after that five grams if you have more then that gives it room to go elsewhere so we now have studies to show that taking 10 grams

“to 12 grams a day can effectively raise your brain creatine levels so remember creatine what it does”

it's naturally occurring molecule and we release it every day but we release it in really small amounts or maybe around one to two grams a day right so when it gets released when we when we take that 12 grams it goes into the brain it helps the brain cells produce energy better namely the mitochondria so it helps the mitochondria produce more energy in the form of ATP and it's been said that in diseases like neurodegenerative diseases like our scientists disease we have an

energy crisis right the brain's trying to repair itself so it needs a lot of energy to do that doesn't have energy right the mitochondria is all dysfunctional we've got plaque to deal with there's so many things that the brain has to deal with in needs more energy so if we can give it more energy then it has more energy to fight right and this is the same thing with depression people don't realize it takes energy to be happy our brain didn't want us happy that's not what

evolution put you know put the brain there for it was here for two things survival and reproduction it wasn't there to make you happy didn't care about that so every day we have to fight to be happy it takes energy to do that and imagine a person who has got clinical depression they're fighting with every everything that they have in their brain to not feel that again to not have those suicidal ideations like it's a it's a brain chemistry problem here and this psychiatrist

that are actually working on these studies and who have clearly showed the effectiveness of creatine on major depression the effectiveness of creatine on sleep deprivation you can almost

eliminate a bad night's sleep with a bolus of you know 15 grams of creatine the first ever pilot

study done on Alzheimer's disease patients very small group 20 groups of Alzheimer's patients not mild cognitive Alzheimer's disease meaning that they've gone to the doctor they've gotten the spinal tap meaning they've gotten fluid from this spinal cord and they've seen that they've got analogue beta which means they've got the clinical diagnosis of Alzheimer's disease took 20 grams of creatine per day for eight weeks and then after the eight weeks they increased their global

cognition scores right they did test the increased their global cognition scores they felt happier their mood increased and on top of that they were able to go to the gym wow yes um people are fighting against this because they're saying but it was only a group of 20 patients I said great that's we have to start somewhere and if you're going to get at that end stage you're going to get somebody to increase their cognitive scores and go to the gym

and feel better why wouldn't you do it but the reason why it needs 20 grams is because

“the barrier on your brain is called the blood brain barrier it becomes dysfunctional that's what”

allows drugs to get into your brain and other drugs to not pass the brain and this can get into the brain okay creatine can cross a blood brain barrier but it takes a lot for it to get past the balancer that's why it takes a lot of of grams of it per day okay well good interesting

I mean it's sounds exciting they've done the first one haven't they oh they did

I forgot about yeah they did the first I mean whoever is deciding to get elective brain surgery

“just for Elon Musk I mean interesting character I think that it's it's scary but look”

do you know what deep brain stimulation is no that's when we can go into the brain we we literally drop electrodes into the brain just like if you were to have a pacemaker and we can stimulate different parts of the brain to do certain things and a lot of neurosurgeons are doing it right now

and it's phenomenal I've been in surgery where they've done that and it's helping in patients with

Parkinson's disease so where you have tremors so patients that you can stop the tremor by doing deep brain stimulation so this shows it's just so hard to do like it's so hard to do to stimulate like the brain is like it's so intricate like when you see like the way it is to stimulate a certain part of the brain to stop doing a certain thing or stop producing its

“actions it's very hard to get to but I think it's phenomenal um neurolink I mean look if it can”

help in disease states like if you can help you walk again maybe I just don't know what he's doing

it for hmm is it would it be possible to to to project an entire false reality and somebody's had with that probably that's scary of course very scary I mean if we can do that with drugs right I've seen somebody very close to me started you know going down a bad path and started with cocaine and ecstasy and then moved on to an Australian we call it Iaseman method and fedamine one with the pipe and induced psychosis and schizophrenia so if you can

do that that's a lifelong thing wow yeah so if you can do that with a dry and I I saw it come alive right over a seven year period so if you can do that with a drug then you could most likely do that with a chip what about marijuana terrible there's it's terrible yeah why is that apart from it's um ability to induce um you know psychosis and hallucinations which happens with um heavy marijuana usage over a given period of time most people are taking it to help them sleep at all but

what they don't realize is it's not helping you sleep it's pretty much sedating you right and so you're not getting into the deep sleep in the REM sleep that we need you're pretty much just sedating yourself and it's highly addictive and it's not doing anybody any good there is a part of the THC plant which is the um the other one I'll see now I need my creatine um I didn't have 10 grams today um it's it's a part of the plant that is actually not psychoactive and it's helping

with patients with epilepsy see see now do I have Alzheimer's disease while cognitive impairment right I'll just malnourish how many people do you guys how many people do you get to think they have it that are just paranoid well depends on your gender your age look I don't think I have um I feel so on points is right now um I can't get that uh CBD CBD oh CBD yes so CBD oil which is part of the the plant as well this is fine it's it's not psychoactive

and it's been shown to help patients with epilepsy okay yeah all right is there anything anything I should be asking you that I'm not I think um I think when it comes to um nutrition like one thing that a lot of people can be doing is they can be taking um omega 3 fatty acids I think it's up there as well if you get it from a reputable brand a lot of the omega 3 fatty acids on the market

“are highly ransered and they exceed the normal oxidation level so you have to make sure you go”

to a good brand but got to tell you like 70 you know 70% of your brain is made of fat right it's fat and water and most of the fat that it's made from is DHA and omega 3s comprise of 3 molecules

literally feeding the brain what it's made of and this abundance amount of research on our

“sign this disease patients and omega 3 fatty acids in fact there is a transporter on the outside”

of your brain MFS 2DA transporter that actually helps shuttle in DHA into the brain that becomes dysfunctional in Alzheimer's disease patients so if you can be helping your brain with omega 3 fatty

acids every day that's another thing that is really good so two grams of each two grams of

of DHA and two grams of EPA per day it's also been shown to eliminate and clear out some of those

“blocks so that's a huge one but look if you are exercising every day at least two days a week”

of resistance training if you are doing your your aerobic training your high intensity training if you're sleeping seven and a half hours a night I say that because PNAs okay it's a very big journal they showed in humans that just one night of sleep deprivation which was classified as six hours or less increases your amyloid beta just after one night by five percent that was a well-established

“landmark study so you don't want that so you want to be sleeping more so I need to get a sleep study”

yeah all you need a stress less no that would be great also that my message is just read more do more do what you can to be happy and invest in yourself you know exercise get outside increase your daily steps per day because we don't we don't realize this in our 20s and 30s but you'll regret it and get your singles vaccine after 50 just singles vaccine yes well doc I appreciate you coming thank you so much that was

so informative thank you thank you thank you what's next for you so many things actually I want to tell me about your consulting business yeah so I take on private clients

and I run them through I'm basically your private health consultant so you can come to me we do

everything from extensive blood biomarkers imaging everything all of it we do yeah head to toe everything every single every single selling your body and whatever goal you're optimizing for whether it's health whether it's longevity um we hope you there so yeah so I'm taking on people I've got an entire team around me as well thank you thank you all right no matter where you're watching the chan Ryan show from if you get anything out of this at all

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