#1 Neurologists: What You Can Do to Prevent Alzheimer's & Dementia

(upbeat music)

I gotta tell you, today you and I are gonna talk about a topic

that gets me choked up because it's that important. And it hits home for both you and me because right now, you have somebody in your life who is either experiencing cognitive decline or they're in the early stages of dementia,

they may not even know it. Or you have somebody in your family who's already been diagnosed or died from Alzheimer's. And this topic makes me emotional because it's something that you and me and everyone

is dealing with in their families. And when you do, it can be so draining and heavy of a topic.

“That's why I called in two of the world's top medical experts,”

neurologists who are the leading researchers on Alzheimer's, dementia, and cognitive decline. To give us both a very specific plan that we can share with our families, a plan that can slow down, pause, and even prevent dementia.

And they're so excited to teach you that your brain health, it isn't just up to your genetics, it's a product of how you live your life every day. And I really want you to listen because the conversation today is about what you can do.

And our experts are gonna tell you, there is so much you and your family can do. There's so much good news, there's incredible research.

It's not too late and it's never too early

to start taking better care of your brain. You're gonna learn about things that you can do right now. They're all based on research. They are free. You can do them today.

“In fact, you can do them while you're listening”

that can boost your chance of not getting dementia by 53%. These neurologists are gonna discuss five specific and simple things that you and your loved ones should focus on. That will either slow down, pause,

and even reverse brain decline. This is such an extraordinary conversation. I'm so glad that you're here because these two experts will tell you. Whether you're eight years old or you're 88 years old, it will work because the recommendations are based on

extensive research and it could add years, maybe even decades to your life. You know, for the past two years, I have been using work in a busy schedule as my number one excuse to not put my health first.

I bet you can relate. Even when I was being consistent with the gym or I was squeezing in workouts, I was seeing little to no change. Why? Because I didn't change my diet.

Well, now that I understand all the research from the experts on this podcast,

I see how critical protein is for me.

And based on what my doctor is recommending, a daily goal of 125 grams of protein per day, I can't get there on meal prep alone. I needed something on the go that tastes great. It doesn't sit in my stomach like a brick.

“That's why I co-founded Pure Genius Protein”

and developed this product with a team of doctors. Some of your favorite world-renowned experts, Pure Genius Protein shots are 100 calories. Zero sugar, zero fat, no artificial flavors or sweeteners, no dyes, just delicious.

And this week, save 20% on your first order at PureGeniusprotein.com. When you use Code Mel, plus there's a 30 day money back guarantee. Cheers to your health. (upbeat music)

- Hey, it's your friend, Mel, and welcome to the Mel Robbins podcast. I am so excited that you're here. I am thrilled about our experts today. It's such an honor to be together

and to spend this time with you. And if you're a new listener, I just want to take a moment and welcome you to the Mel Robbins podcast family. I am grateful that you're here.

The conversation today is so important. And I'm glad that you're listening not only for yourself, but I hope you will share this with everyone and your family, because what you're about to learn is gonna give you hope. And based on the research that you're about to hear,

it could add years even a decade to your life. It's gonna make your brain healthier. And everything that our medical experts will recommend is free. Today, we are talking about memory, dementia,

and the brain health framework you need with two of the most respected voices, researchers, and medical experts in brain health, dementia, and Alzheimer's prevention. Dr. Isha Shirzae and Dr. Dean Shirzae

are here today. They are board certified neurologists,

and cognitive decline.

They've spent decades studying neuro-degenerative diseases.

They are also a married couple who have trained and worked at some of the most prestigious academic institutions in the world, including Georgetown, Columbia, and the NIH. They both currently work at Charles R. Drew University

of Medicine in Science, where Dr. Dean is the executive director of Clinical Research and the Director of Community Core. And Dr. Isha is a professor of neuroscience and director of the Inspire Research Program. They are the former co-directors of the Brain Health

and Alzheimer's Prevention Program at Loma Linda University, where they studied the healthiest people in America. The Loma Linda's seventh day Adventist Population, and also co-directed the Brain Health and Alzheimer's Prevention Programs at Cedar Saiyanae Hospital.

They are also the authors of the best-selling book, the Alzheimer's Solution. Please help me welcome Dr. Isha and Dean Shirzae to the Mel Robbins podcast. It's so wonderful to be here, Mel. Thank you.

Thank you so much. Thank you for jumping out of plane. Thank you for taking time out of your busy schedule to fly across country and be here with us in Boston. We are so excited to have you here.

And I want to start by having you speak to me and the person that's with us. What could be different about my life or the life of people

“that I love based on everything you're about to teach us today?”

I'll tell you that this is the most important system

that we're talking about the brain. This little brain. Oh, and he's picking up a brain already. Dr. Dean's got a brain in his hands. This brain that's supposed to be three pounds.

Two percent of your body's weight consumes 25% of your body's energy as much as 40% of your oxygen at times. This brain is constantly working. It has 86 billion neurons over one trillion potential connections.

It's the most active organ in your body. And arguably, the most active and adaptive organ in biology. What does that tell you? It's the change or end. And here's the most important part.

The change part is in your hand. Whether you're nine years old or 90 years old. This is an important topic that we need to talk about. And when the listener leaves this conversation, we want them to feel empowered to take care of themselves.

Nothing magical around it with things that are easily around them. Things that they can start today. Beautiful. So, Dr. Isha, I want to stay right there for a second.

“Because I think if you're my age 57 or you're 60 or 70,”

you're thinking about dementia. You're thinking about memory loss. You may have somebody in your family that has been diagnosed with Alzheimer's. But if the person that's listening right now is in high school

or their 20s or their 30s, what could change about their life

and why is it critical that they listen to this episode

and share it with people that they care about? - That's such an important question. When the word dementia comes about, we always think that that's a point. That's a diagnosis that happens later on in life.

But when you actually look at brain health, it's like a spectrum. You kind of build your brain. And if you don't take care of it, the wear and tear will accumulate over a period of time,

and a time will come when cut that damage is irreversible. And I'm not trying to scare the listener. - Well, I don't mind if you scare us,

“because I think we need to hear the truth,”

because I think most of us start thinking about dementia, when we get to midlife or if we have a family member that gets diagnosed or we start to feel concerned about it. But you're here to tell us the facts based on research and your medical expertise,

which is that this starts way earlier. - It does. It does. And I'm glad that you put it that, when I'm glad they were talking about it,

because as a neurologist, I sit in my clinic and I have a schedule day packed with people coming in with problems with their memory, and then my job is to kind of diagnose them with dementia. And that is a stage where the damage is so profound,

and so conspicuous that there's not much one can do. There is a lot you can do at that stage as well. But how wonderful it would be for us to actually start taking care of our brain early on. So if you are in our 20s or 30s,

things like going to sleep on time, waking up on time, making sure we exercise, making sure that we take care of our stress, which is really ravaging our brain. Making sure we eat well and have a diet or a pattern

that we like containing one for a long time. Those things matter, and they make a huge difference for our brain. I would love to just ask you both, what is dementia? Yeah, so dementia is an umbrella category.

and your memory affects your daily activities.

“And there are many different types of dementia.”

60 to 70% of dementia are Alzheimer's dementia, so it's the most prominent type of dementia. And that's why the word Alzheimer's is used synonymously with dementia. It's actually a type of dementia.

Another type of dementia is bascular dementia when the blood vessels in the brain are damaged. And then there are other smaller ones like frontal temporal lobe dementia, Huntington's disease, Parkinson's dementia,

Louie body dementia. And most of them essentially impact the way you think, your memory, your decision making, your processing speed. And it's something that doesn't start by the way, like we were saying it earlier.

It's a cumulative damage in the brain that causes this condition. There are multiple different types of protein. It, one is called amoloid beta protein, another witness called tau.

And what happens is over time, they start damaging the inside of brain cells on the outside of the brain cells. And there are different ways of actually looking at the brain to understand what kind of dementia people have. Dr. Dean, you know, after reading your best celler

that you two wrote together, the Alzheimer's solution, I'll tell you what caught me was at the top, radically reduces risk of Alzheimer's disease by 90%. One of the things that I realized is that brain health is just one of those things that you don't even think about

until it feels like it's too late. Is it ever too late to consider your brain health? I want to approach this carefully, because there are cases where it is too late. And that's where advanced Alzheimer's.

There's a lot of people that are actually making money off of people's fears. And this is the biggest fear. When a person has Alzheimer's or the family, and the patient are desperate, and guess what?

When there's desperation, people go after that desperation. And I want to make sure that people understand that there is no way to reverse advanced Alzheimer's at this point. You can slow it down, you can work on quality of life, which is as important, helping families with their journey,

I should not sit down with the families for hours, telling them what they're about to face, what to do, and most importantly, how to give this person this going through its battle, quality of care, and don't fall for the gimmick of the day.

But for the great majority of those that have three Alzheimer's or early dementia, or MCI, which is right before dementia, a significant portion of those population can be helped to prevent or delay significantly. And that's incredibly important.

If we can do that, even at 60%, which is the number that's been proven,

“what do we want to be say, 90% of you are extrapolated?”

I'm always careful not to separate science from extrapolation.

But even 60% were talking about millions and millions of people whose lives will be changed. And that's very important. And I want the people there to know that every family now has somebody that has Alzheimer's or some other type of dementia.

And all of those can be affected if we get it, early enough. I love that you can pause or slow it down. You also use this phrase, MCI, that happens before dementia. And I felt myself leaning in, what is MCI?

MCI stands for mild cognitive impairment. And this is where a person is having significant memory issues, significant focus issues. But everybody has that. So as soon as I say that, people get here.

No, significant to the point that it's really to some extent affecting their daily activities. They can still drive, they can still do their finances. But themselves and the family is noticing that this is a little different than the past.

And give me a couple examples of what might be MCI.

“And because I think we've all, like I love that you said,”

every one of us has somebody in our family. Yes. That is diagnosed with dementia or carining right into it. And I think we've all been at that point, whether you're talking about your grandparents,

for your parents, for your like, well, they're just kind of losing it. They're not really themselves anymore. They're slow at like their ways we talk about it. But could you give a couple examples of just like what you might see in this MCI stage or super early stage?

So let me tell you what's normal. Okay. You're going to the kitchen and have free there. You forgot what you were trying to do, right? Yes.

That happens daily. Because memory is focus. And I'll talk about that. Focus is the gatekeeper. Focus is the currency.

So, as you get older, you have lots of things affecting your focus. There's a little pain in your knee. The work, the podcast, the people calling, the problem with the end laws or family members in good way. And I don't mean it, the balance.

But all of these things are in the back of the mind. Yes, those are the ferrets. So of course, when you were trying to go to the kitchen,

you're supposed to first encode that memory before you go.

when you're older, there's all this piece of information interfering

“to never put it in the right file folder,”

you go there and you try to grab it, it's not there. That's normal. Okay. But if it happens every day, every minute, there's something going.

If you're forgetting closer family members' names, not just once or twice, but on a daily basis, they're stopping you. So then, even that, it's not necessarily dementia. It's something to be addressed.

Go to a neurologist, get it evaluated. They'll do imaging, they'll do blood tests. They'll do, to make sure that's not the 12th efficiency or a thyroid disorder. Something that makes sure that's quickly reversible. And they can figure out, this is what the stage you are in.

And we can really influence its significant. And the reason is, because what you're about to teach us is there are evidence and research backed things that you can start doing right now that slow or pause the onset of things getting worse.

Absolutely. That's really hopeful. It's incredible. And for those that don't have this, start now, because it's not just about pausing,

how about growing your brain as you get older? We literally see brains grow on MRIs. People who do X, Y, and Z, the things that we're about to speak about. They grow their brains well into their 80s, 90s, and beyond,

because the brain is that active. That has that much capacity to grow. And it's incredibly hopeful. Dr. Dean, do you believe that our overall brain health as a society is getting worse?

In many ways, yes. The reason it feels like it's getting worse. And it is. The numbers are there. It's not necessarily dementia increasing,

but that risk is increasing as well. It's because we have so much more happening to us to our brain, to our focus. Our focus, as I said, is the gatekeeper, is the currency of our consciousness.

So the way you spend that currency matters. I want everybody in the audience to recognize that you have to be aware of your focus and where it's being spent. And in a world where your focus is being stolen, systematically

through the social media, the systems, and machinery that tries to pull your focus, we have to be careful. Because if your focus is three seconds at a time,

you're never going to get to better memory.

Because without a focus that goes deeper, memory doesn't happen. Without a focus that goes deeper, deep thinking, an executive function doesn't happen. Without a focus that can go deeper and sustain, your emotional stability actually is flipped

to an urgency living, which is this fight of flight state, which is incredibly destructive. So it starts with that in the world we live in, which is constant attack on your focus. - What do you think the most common habit that you both see

is that's harming people's brain function, and we may not even realize it? - I'm making a generalized statement, but something that I see quite often is stress. And we define stress in different ways in our lives,

but stress is such a powerful contributor to cognitive decline.

“- Why is that contributing to cognitive decline, doctor?”

- Yeah, so it essentially changes your biology. What people are under stress, and I have to say bad stress, because there is such a thing as good stress and we'll talk about that later. When people are experiencing bad stress,

your body stress creating specific neurochemicals and hormones that don't allow information to be stored in your brain.

How you basically are kind of closing all the gates

for creativity, for memory, for processing information, and you're in this constant fight or flight situation where your heart rate is up, and you're chronically going through biological shifts in your body and formation goes up, oxidative damage goes up,

even if you're quiet. If even if it's not really showing on the surface, on the inside, stress literally eats up your brain. As a matter of fact, there have been some studies that show that when people are under chronic stress,

they actually have smaller brains. There's a part of the brain called the hippocampus, and the hippocampus is responsible for many things, but the primary function of hippocampus is encoding memory. That shrinks when people are under chronic stress,

and cortisol is out. So it affects your brain and affects your heart, it affects your arteries, and it's really important for people to kind of take and account of what their bad stressors

are and do something about it. Is this why, if you just think personally, and as you're listening or watching right now, think to a moment in your life where you were under so much pressure,

is this why those periods of your life, you sometimes look back on and later,

“and you're like, I don't even remember what was going on,”

because my life was so stressful.

- Absolutely, stress basically is fire flight.

So you have these two primal states, fighter flight, and reproduce and build,

These two systems are the primary driving force of the brain. When you're in constant stress, you're in fire flight. Fire flight means your GI system shuts down, your growth, as a hormones shut out, your cortisol goes up, your bones actually starts resorbing

and not building, every system you can think of, including immune system, sexual activity, everything closes, and in during that state, you're front to low closest, because you are not worried about thinking your way

out of the grip of a tiger, you're just running. It's fighting the tiger, and if you're fighting the tiger constantly, none of the growth states matter, and the brain and the body knows that, shuts them down.

So chronic stress is that's that bad.

And then the second part, the second part of that is,

when you're a constant stress, nobody is going to be able to stick to a very disciplined nutrition program, because you're going to go to survival nutrition,

“which is in the back food, just to get the calories, right?”

You're not going to be doing exercise. It's about doing what makes you just comfortable. You're not going to sleep well. What's the number one factor that affects sleep? Stress, mental activity, your frontal lobe closes,

everywhere else closes except the limbic emotional brain. Stress is that destructive both within the body and general, the brain and would have it. You know, one of the things that I love about your work is not only the fact that you're doing research,

and you're in these big clinical practices, but you're also in community outreach programs. You've built the largest brain outreach program in communities nationwide, which means you're seeing people of all different ages.

Because I think probably if you looked at the data, you got more people going into hospitals for screenings that are older, but I'm curious, how young are you both starting to see the effects of cognitive decline in brain health in people?

- I love that you said cognitive decline, because I have to be honest, we don't see dementia earlier, because that's later on. But cognitive decline definitely.

“And we're seeing quite a few in the communities,”

right now we're in community churches, and we thought that we're going to see people in their 60s, 70s, or later. We're seeing people in their 40s come to us, and saying they're having cognitive decline.

And when we test them, we detect the cognitive decline. Why not? That doesn't need that they have dementia, that might make them address for dementia down the screen, but we know that they're having

these cognitive issues early on. And at the same time, it's incredibly positive because we captured early. And in the hospital and clinic, because hospitals and clinics are fantastic,

but they're fantastic for sick care, which we see people at the point of disease, once they have dementia, once they've had stroke, once they've had heart attack, you see people way earlier in the communities,

when they haven't had that yet, but you're seeing the beginnings of it, or if we detect the beginnings,

that's the powerful work in the community.

- I love that. One other thing that I read in your book, Dr. Isha, is that there are seven stages to dementia. You've already taught us that Alzheimer's is a slice of dementia, even though they seem to be used interchangeably,

and that we can be in the first stage, so pre-clinical stage 20 years or longer, and I want to read to you from your best selling book, the Alzheimer's solution. This is on page 61.

A person in stage one has no impairment, no memory disorder, or cognitive deficits, though I'm going to say this word wrong, but am Lloyd? - Yes.

- Okay, I said that right. Am Lloyd plaques and tau tangles may be accumulating in the brain, Alzheimer's and other dimensions begin to form years and often decades before they manifest. There may also be inflammation, vascular changes,

and atrophy in certain parts of the brain, but not enough to cause symptoms,

and this first of the seven stages

of dementia can last 20 years or longer. - Yeah, that sounds scary, doesn't it? - Yes, I'm like am I already in it?

“Like, probably, but I think it kind of ties back to”

what I was saying earlier. I think if we think about brain health as a spectrum, and not something as like healthy for non-healthy, yes, it will make sense. - Now are we all going to get to bed,cha?

- No, that's the whole point of having this conversation, right? - Okay. - What we do is throughout our life. You either are living a life that is taking care of that magnificent organ, or you're contributing

to its damage.

if you kind of like think about it,

it's like a wear and tear. You have this beautiful machine, right?

“You have to oil it, you have to just keep it away from moisture.”

You have to make sure that it's not exposed directly to the sun, you have to make sure that you keep it clean. Like, yeah, I just got myself a cuisine art, like that's, you know, that makes your stand, and it requires a little bit of maintenance.

- Yes. - And the why I'm bringing that analogy, because it's a pain in the rear end of clean. - That's why. - Yeah.

If you kind of just let it be, then it's going to not work properly. Singles for the brain. You really have to put in the work to take care of it. And so if we don't, even if we're in our 20s and 30s, like we were saying earlier, a bad night sleep,

not eating well, choosing a sedentary life, having poor relationships that is constantly creating stress in our life, not really pushing ourselves to learn something new, to experience something new and be creative.

What happens is your brain starts accumulating these bad proteins that you just talked about, amulet, beta protein, and tau-tangle. And after a while, that damage really shows itself. Like, when we actually do MRI imaging

of our patient's brain, right? You can actually see white spots. We call it white matter disease. And that could be related to that blood pressure. It could be related to high cholesterol.

It could be related to loneliness and social withdrawal, not treating sleep apnea, and not living a healthy lifestyle. So you can actually be in that stage

for decades before the first symptom of like,

forgetfulness comes about. That's what we meant in the book. - Now, if you've had concussion damage 'cause I keep thinking about the fact that so many people listen to this podcast

within families, does that put you at greater risk for developing dementia or any cognitive decline later in life? - It does, it does, but there are different degrees. If people had a significant head trauma,

of course, the risk goes higher. - Yes. - Or if you had multiple smaller head trauma, again, same thing. So I want people to know that the head trauma

is a major contributor. And we have to take life with that in mind. We took it for granted that the brain was going to be fine because it's inside that bony skull. That bony skull has ridges.

And the fluid that covers the brain is not viscous.

So it's not slow motion, it doesn't slow the, it's literally bouncing off the bone. It's, so we have to be careful with the activities we're involved in. I'm sadly even, I played soccer.

And, sure, stop the tennis. They even soccer players that do multiple headers. They've seen that that actually affects the brain. And activities like boxing and traumatic brain injuries absolutely contribute to that.

Now, the good news is, if it's a few head traumas, like the things that I should just said, a few things that happened during a year, would get reversed. The good things that you do can significantly offset the bad things.

I would rather that people don't do the bad things because we don't know when you'll be overwhelmed. But the two are has to be taken into consideration. - I wanted to add something. - Yes, please.

- And I think it's really important and people might find it useful. When we expose our brain to something that could potentially harm it, we don't feel it when we're younger.

We actually don't have any pain receptors in our brain. - You don't? - We don't.

“So that's why I don't know if you've actually seen”

these neurosurgery videos where you don't, they have somebody skull open up and they have their eyes open and they just kind of poke at the brain and the person is playing the vile

and to see which part of the brain they're touching. The brain itself doesn't have any pain receptors, the covering stew. But my point here is, the brain has so much reserve and capacity

to kind of make up for a deficit earlier in our life. - Yeah. - So you actually don't feel it. One of the reasons why people don't care about their brain health just like even if they drink too much,

even if they miss many nights as they define, right? They don't feel it. Had it been your skin, if you keep on slapping your skin, you're gonna get a bruise.

You're gonna be like, oh gosh, I see it. I see it. - Right. - But we don't see or feel the damage to our brain because it has such resilience.

It's a very, very code of quote, plastic organ. It makes up for those deficits. But the damage is happening, unfortunately. - Well, I love that you said that here's why.

“Because common sense, I think we all know,”

if you're smoking, you're damaging your lungs. If you're eating, ultra-processed food, you're damaging your GI tract, and some of your other organs, if you are sedentary, you're not doing a lot

for your overall health and your muscles. And what I'm gathering from this conversation and also from the lifestyle interventions you're about to talk about that are within all of our reach

in our brains, that just like smoking damages your lungs,

it's damaging your brain. Just like alcohol is damaging your liver, and you may feel the hangover in your body, it's damaging your brain, and just thinking about it holistically,

that this organ that is literally, what's keeping you alive is affected by everything you do, but we're not thinking about it. And that's why this is so important. - Incredibly well said it.

And I would go as far as say, you're probably affected

“and brain more, because remember, really?”

- Oh, it's a three-pound organ, but it consumes 25% of your body's energy. It is the most vascular organ you would think that the heart is the most vascular. The brain is the most vascular organ in the body,

so it would talk you about smoking.

So smoking affects the lungs,

the vascular of the brain is affected significantly more because there's more of it. I wouldn't block pressure affects the peripheral organs. The brain is profoundly more affected because of the vascular.

When you're having alcohol, it directly kills neurons, and more than killing neurons affects the connections between neurons and affects sleep and everything else. So we usually say, if you take care of your brain, you've more than taken care of the rest of the body,

because the brain's the mass, it's resilient, but its demands are tremendous. - Thank you for saying that. I'm so grateful that you're here. I'm also grateful for our sponsors,

so I want to take a pause, so we can give our sponsors a chance to shine. I also want to give you a chance

to share this episode with your family,

because everybody in your family deserves this life-saving information and don't go anywhere. We have so much more to dig into with Dr. Isha and Dr. Dean when we return, stay with me. (upbeat music)

- Welcome back, it's friend Mel Robbins. Today, you and I are here with two world-renowned neurologists, Dr. Isha and Dr. Dean Shersai. We're talking about memory, dementia, and the brain health framework that you need

and exciting new research and a protocol that can help you slow down, pause, and even reverse brain decline. All right, let's just jump right back in. My next question is,

Dr. Dean, how much control do people have over their cognitive future? - More than any other order. Your brain is at your control. It's there to answer to you constantly.

Your brain is growing constantly and is growing in relation to what you do to it. And it's also shrinking in relation to what you do to it. - Oh, I don't like that. When you said shrinking, it made me feel bad,

'cause you don't want to make me think about, it's like, this may be too much information, but you know, you think about hydration. We all need water. If I go the bathroom and I see that the urine's a certain

problem, I don't like not hydrated, but I'm not thinking that my brain needs water. And if I'm not hydrated, my brain's shrinking a little bit.

“And I think that's a really compelling thing to think about.”

- It is beautifully stated, and it's compelling because it's visual, but it's even more real for the brain. So nutrition, sleep, and stress management creates the environment for the brain to grow or shrink.

The two things that grow the brain and by growing connections between the rods, your neurons can have two connections? - Oh, they're pulling out a visual. I'm excited to see this.

Okay, let me describe this for the person who's listening. They're holding up just a kind of a white board and you've got two blue dots on either end and then they're connected these two blue dots by just two red screens.

- Yes, and the blue dots are the blue things are imaginer, it's the neurons. - Okay, so the blue dots are neurons. - And the connections are the external connections between the neurons.

- How do they call it? - The external connection. - The external connection.

“- Yes, that's how they communicate with each other.”

That's how we actually think. It's the communication between neurons. - Got it, now do I need the neurons to be connected in order for my brain to grow? - Oh, absolutely.

- In order for your brain to even survive. - So brain health requires your neurons to be able to connect to each other. - Yes, and these connections can be made at any stage of our life.

That's the cool thing about it, you know? We may not be able to grow many brain cells, but we can make so many connections between the brain cells that we already have. Each cell can make as little as one or two connections

or as many as 30,000 connections. - Depending on how you take care of it. You're holding scissors, so I don't know what you're about to do. - Well, this is this is what happens. If you have an equal, if you haven't challenged your brain,

a couple of connections, right? Couple of axons. And one night, you had too much alcohol and one of the strings is cut. - Oh my gosh, he was so sad, he did.

So if you're listening, he just cut one of the strings and now these two neurons are hanging on by one thread. - Yeah, and then another, you were just walking or you played or playing sport and you had a head injury. And the other, they're not connected anymore.

- They're not connected, and not only are they not connected

and most of the time, they never connected.

- And that's it, it's gone. - Now, that's so depressing. - It is, but here's the--

“- Is that what you mean by your shrinking your own brain?”

- Right, because you're killing the connections between the neurons. - Absolutely. - Okay, they've got another visual. Let me explain this to the person who's listening.

So now they're holding up a second visual. It's, again, two neurons, but this time instead of two strings, there's like tons and tons and tons and tons and tons and tons of strings connecting them. - Correct.

- And this is not even a good representation. This is probably 50 connection. We're talking about 30,000. - A million thousand. - A million thousand.

- Now, this is one neuron and then connected to another neuron. Now, this is because this person has kept them by an active, they've challenged themselves. They've exercised, they've kept, you know, good nutrition and all of that.

So, you by doing that have created the conditions for the neurons in your brain to grow and connect and communicate with each other, which increases the health of your brain. - And thousands of studies have shown this to imaging studies,

to pathology studies that people that have challenged itself, that have kept their brain healthy, have way more connections. Now, this brain, let's say the same thing is the previous one.

“One night they drank and one of the strings got caught, right?”

- Okay. I still don't like, I don't like it when you come because I feel my brain going, "Don't do that." - Yeah, one brain, and then another day, they had head trauma, another one, bro.

Guess what? - Oh. - Still, all the rest of the connections are there. - Right. - Let's see, a bunch of other things happen. - Now, he's cutting a lot. There's a lot of strings hanging down.

But you still have the connection between the two. - And here's a beautiful part. Not only are those connections continuing the work, the fact that they're connected, actually later on, allows these two notes to make

further connections again.

Dax the incredible story.

That's incredible, hopeful story. By the way, those connections can be made at 80, 90, even 100 years of age. - Now, if you have dementia, can you continue to make connections? - Yes, you can, you can't, but the thing it.

If you have advanced dementia, by then, the mechanism of the instructions through Tao and Ameloy is so profound that it's difficult to reverse, but I think-- - You can slow it down.

“- The really important thing about this visual”

and it's so powerful is that as long as you don't destroy it all, and the neurons stay connected through the lifestyle and research back things that you're going to tell us to focus on, you can help your neurons in your brain

make more connections, even if you've done some damage earlier in your life. - That's a very empowering statement, and we see it clinically in our patients. Say, for example, if someone has had a mild stroke,

or if they've had traumatic brain injury. In stroke, what happens is, some of your brain cells die,

and they never come back, but with physical therapy,

with a healthy lifestyle, with cognitive therapy, you can actually strengthen the connections between the self that are already there, and sometimes they can take over the function of the cells that are lost.

It's so wonderful to actually see people recover even after major injuries or major strokes when they start living a healthy life and implement these life-self. - Can you bring that visual back real quick?

'Cause I want to ask you a question related to stress, and the visual that has a bunch of different connections. So let's say you've been taking very good care of yourself, but now you're in a caregiver role, and you talked about the fact that, you know,

Dr. Isha, when you were talking about the things that create damage to your brain health, one of the biggest ones is stress and chronic stress. And we now know that caregiving is its own form of chronic stress, and I was startled reading your best-selling book,

the Alzheimer's Solutions page 46, partners of those who develop dementia, have a six hundred percent greater risk of developing the disease themselves compared to the general matched population.

And this isn't attributable solely to stress that shared lifestyle risks are also a major factor in the health outcomes of long-term couples. I'd love to have you just grab the scissors and just show us kind of like how stress

and caregiving really can break apart these connections and neurons because you're so focused on somebody else.

- So what caregivers are under tremendous stress, let's say their cortisol level is high. That kind of cuts off towards three different connections of showing cells. Let's say for example, they don't get a good night's sleep.

We know how common that is among caregivers. You'll brain didn't get enough time to cleanse itself and to function properly, let's say, for our five other connections got cut off. Let's say you don't have time to walk

or to exercise, forget about it. You have some other connections cut off.

Let's say you never really get time to do something creative

because you're just stuck in this constant mundane lifestyle of doing something over and over again. Creativity doesn't allow for your brain to grow at all. And then on top of that, just the sadness and the pressure of taking care of another person,

the guilt that comes with it, the shame that comes with it, all of that actually just severed the beautiful connection between brain cells.

“And that's what puts people at a high risk.”

The other thing is, when you live with someone who has Alzheimer's disease or some sort of dementia, lifestyle matters too, so you kind of share the same environment to you kind of eat the same foods that they do. Let's say for example, if they were not eating healthy food.

Yes. There you go. - Wow. - Connection severed. They were not really into exercising.

There you go. You kind of follow that pattern. And as you can see, there's a accumulation of all of these risk factors on top of the stress that you're experiencing and care gets us a lot.

- I am so grateful that you brought this visual example. And if you're listening, what just happened is every time Dr. Isha talked about those very real circumstances that caregivers are experiencing. She was cutting one of the strings that connected the neurons

“in your brain and it was extremely compelling and dramatic”

to see the connections and the strings hanging down.

Because this is the first visual example

that I've ever experienced, that really demonstrates to you as a caregiver. Why taking care of yourself, getting sleep, eating right, staying connected to friends, that you hear the adage put your oxygen mask on,

it does matter because while you're caregiving, if you don't take care of yourself, your brain is shrinking. And there are things that you can do to stop that from happening or to build more neurons back.

If you've been in a period of caregiving and now you're coming out of it so that you can, but this to me raises the stakes in why the interventions were about to talk about matters so much. - One other point that I have to be here.

- Yes, a large percentage of population, your population has women. - Yes, two-thirds of all caregivers are women.

“And two-thirds of all Alzheimer's patients”

that dementia patients are women. And they are usually caregivers when they're misleaf. They're going through menopause and everything else. That's not a sad thing. Here's the positive part of that.

If they just are aware of that fact and they do one or two positive behaviors and activities in their life, that is a significant change in respect. So for women, especially they should know,

majority of the women that we deal with are, you know, they're thinking of their children and their mother. - And then they're going through their 40s and 50s like you said. - Has estrogen drops in your hormonal system and the expectations that are put on you

from the society, all of that takes a toll. - Thank you so much for explaining that. I really get it. And I know as you're listening, you're getting it too. And I also know there's people in your life that you need

to share this with. I'm thinking about my best friend from childhood and her dad is going through cognitive decline. I'm sending this to her right now. There's somebody in your life that's caring

for an aging parent that has a spouse that has been diagnosed or that's in the early stages of cognitive decline. This is such a life-changing resource. So please take a moment and send this to somebody that you care about.

Whether it's your parents, your aunt, who's not taking her health seriously, somebody that you care about at work that's caregiving for somebody with memory issues, even send it to the young people in your life

and let them know it's never too early

to start caring about your brain health. And what we're learning today is it truly matters. All right, don't go anywhere. We have so much more to dig into when we return, stay with me. [ Music ]

Welcome back at your friend Mel Robbins. Today you and I are here with neurologist, Dr. Isha and Dr. Dean Shurzai. Talking everything memory dementia and brain health,

that they recommend to their patients that can pause, slow down, even reverse dementia. There is so much more I want to dig into. So let's just jump right back in. Well, I really appreciate your work

because you have simplified the things that we need to focus on down to five things. Dr. Isha, it's a word, neuro, N-E-U-R-O. Can you walk us through the five things that we should focus on?

And if you're a caregiver, ladies, wake up like this is what we need to do to keep our brains healthy. Thank you for bringing that out, Mel. We kind of kept it simple for our patients and our community members

“to remember these five pillars because they make a huge difference.”

So N stands for nutrition. It's not about superfood. It's about what kind of dietary pattern you choose and I'd be happy to talk about it later. E is for exercise, moving, movement is a life.

It's connected deeply to how we feel about ourselves and how our brain grows. You is for unlined, which is stress management. Producing baths stress, increasing your good stress.

All stands for restorative sleep, which basically

means the deep kind of restoring sleep that cleanses your brain and makes it ready to memorize and de-creative. And all stands for optimizing cognitive activity. Doing specific activities, leaving a meaningful and a purposeful life and engaging with your environment and your social life

so that you can grow the brain. So doctors, you're saying all we have to do is focus on better nutrition, moving our bodies, unwinding, meaning just address some of the big stressors in your life, mindfulness, deeper rest, prioritizing sleep, and then optimizing some of the cognitive functioning in terms of just

learning something or engaging in things that expand the way that you think. That's all we need to do to take better care of our brains. These are the core lifestyle measures that you can address, and yes, you can take care of your brain. This is how we can pause the onset of dementia.

Let's put it this way. Take nutrition alone. If you eat at nutrition that's healthy and it's simple,

“it's not any, you have to buy anything from anybody.”

These are simple things from any grocery store. We work in Crenshaw, we work in Central LA. Things that you can find anywhere. The studies have shown, mind study, that just good nutrition reduces your chance of Alzheimer's by 53%.

53%. Your brain is incredibly forgiving and resilient. And I mean that in a physiological stance, because this brain doesn't hold guilt or memories of a blame, or why did you do it, it recognizes the thing that's in front of it.

So if you put the right thing in front of it, it literally overnight changes. It's sort of like a plant. So you might have a sad plant in the corner, but if you give it a little sun and some water,

it'll percreate up. Is that what you're saying? That's the perfect analogy. Now, Dr. Dean, before we go deeper into each one of these habits, because once you said 53%,

like that was incredible just talking about nutrition,

can you share more about why each one of these five habits matter so much for your brain health? Absolutely, because they're cumulative. At the same time, you could do one or two of them, and you would still benefit.

But if you do several of them and there's a study that actually shows this, when people that one or two of these habits, they reduce their chance of Alzheimer's by 30% or so, when they did four of them,

they actually reduced it by 60%. 60% reduction? Yes. By following these five simple habits? Correct. And it's powerful because cumulative. So if you do just walking,

we're not talking about some kind of marathon running. Just daily walk. You've reduced your chance significantly. In fact, one Harvard study showed that if people walked risk walk 25 minutes a day,

just a risk walk, 25 minutes a day, they reduced their chance of Alzheimer's by 40%.

Wait, hold on a second. Yes. Yes.

I mean, that just sounds honestly insane that you could reduce your risk of Alzheimer's by 40%. By taking a 25 minute risk walk. How many days? Just every day? Five days a week. Well, and so, and if you're listening to this podcast

and walking right now, you're doing a two-fer. You're not only learning, but you're also doing something that improves your brain health. You know what else is cool about that? It's free. It's free. You're right. Absolutely.

And whenever we talk to our patients, we try to create this picture of you accumulating these coins or, you know, like creating a brain bank account. We actually have a model here

“that if you want to pull out the marbles,”

so basically have two jars in front of us.

I want to tell you right now what's happening. There are two big Mason jars.

“And one of the jars is about half full of clear marbles,”

and the second jar only has like a little bit of marbles. So I'm just going to take a guess that the person on the right that has just a few marbles in there, party to lot, didn't get a lot of sleep, has had a lot of concussions and is caring for people.

And so it feels like a lot of the connections between the neurons have been destroyed.

No judgment. No judgment. No one will never.

Yes. The one on the left is about half full with marbles. So this is somebody that's eating better in that kind of stuff. So the jar that has less marbles is someone who really didn't invest in their brain health, too. Okay. So say for example,

they didn't take that, you know, dietary patterns seriously, or they didn't take sleep seriously. So they really don't have a lot to lose over here. And say for example, if they have one night of bath sleep,

I'm going to start pouring the marble out of the jars.

Now you have less, right?

And then let's say for example, another time they just decided to kind of just let go and just eat a lot of, you know, unhealthy food, junk food, and not really getting all the blueberries and good fats in there. And then what? We're going to lose some more marble gear.

And now you're luck with very little. Now the person who has actually invested in their brain, and they've accumulated all of this positive energy and protection for their brain. Let's see something bad happens to them. Even if they actually start having safer example,

they've had a small little brain injury. They're going to lose a little bit of marble here. We give what they still have a lot there. Yeah. They're really not going to run out of that cumulative benefits for their brain health. So this is essentially a concept of cognitive reserves.

Oh, I got it. So the more you focus on these five lifestyle changes that we're going to unpack for you. The more you're investing for the future, so that if something happens, caregiving for a couple of years, if something happens, you have a reserve of healthy deposits in your brain

“to get you through it. Now does the opposite also work?”

You haven't been good. You're now listening to this or watching this. And you're like, oh, because I know that this is an episode that so many of you are going to be sharing with your parents and your grandparents and your brothers and your sisters. And you may have received this in the family group text chain. And now you're listening, thinking, oh, my God, I'm screwed. What am I going to do?

Does it work? The opposite, meaning every night's sleep. You're now starting to deposit.

Okay. That's a beautiful segue. The reality is, let's say you're 50 years old or 60 years old.

And you have this little reserve. Yes. But now you start with nutrition. Can you are eating a very healthy nutrition? You remember, 53%. We are talking significantly now you're walking every morning and doing some leg exercises as well. We'll get to that. Now you have all of this. None of the marbles are coming out of the brain. It's good because it's filling over. Good health. Now you're actually managing your stress. And then you're sleeping better. And now also you're

challenging your brain. You're creating relationships. You're socially active. You're doing creative stuff. That's a full bank account. You know, you know, you don't also loved about this is that we've all seen those videos online of grandmothers and grandfathers at the gym, pump and weights to prove that if you started any age your muscles can respond. And what I love about this visual is that even if you're listening right now and you have not done a good job

of taking care of yourself, you can start today and it will make a enormous difference in your brain health and how you feel and more importantly what you're saying is based on the research we're going to go through each one of these five things that you want us to focus on. You can pause dementia. You can slow it down. You can protect yourself from getting it the earlier you start. Absolutely. It kind of ties back to that question you asked about why should people

worry about their brain health and their 20s and 30s? This is why. Well, and I also love this because there's so much noise out there about longevity and people injecting themselves in this thing and that thing and the other thing and like all this crazy word stuff and you're just saying, hey, there are five things that based on all of the research, based on all of your expertise,

“this makes a significant difference. One of the things that I think is super cool about you is”

that during your neurology training at Columbia University, you became a professionally trained chef.

attrition and I felt so disempowering to cause just pat them on the back and say, eat healthy, was there even meat, eat healthy? It in these different things for different people. Or, you know,

I always to pride in being very evidence based and I would bring up mind diet or Mediterranean

“diet, but what is Mediterranean diet mean for someone who lives in cranchol Los Angeles, California?”

And so I thought, no, I think I think I need to know this better because at the end of the day, it's you and your kitchen, it's you and front of your fridge, making decisions about what to put in your body. And if I'm not specific and if I'm not empowering, I'm not doing anything. So I'd be in the ICU in the mornings at Columbia Presbyterian and then, you know, right after work at 7 p.m. in my scrubs, I would run down to, you know, the cooking school in New York City and I got my degree

into years and I've been teaching my patients in my communities how to cook. So let's put us right at that spot that we all plan what we're eating, which is standing in front of the fridge with

the doors open or standing in front of the cupboard with the door open. What do you want us to have

in our fridge or our cupboards in terms of the options and what we should focus on for better brain health?

“So when you look at the different studies that have been done, the show, what kind of food”

matters a brain health is not, you know, one or two foods that stand out. It's not a super food of the day because we all hear that in informal mursholes and, you know, people stock up on specific foods. It's the kind of dietary pattern that you have, the different types of food that you eat. And, um, whether it's the mind diet or Mediterranean diet or all these dietary patterns that have been studied extensively, it's a variation of the scene's feet. They're mostly plants.

So you have your greens, leafy green vegetables, you have your crucifers, vegetables, like broccoli,

cabbage, cauliflower. You have nuts, like walnuts and almond, you have seeds, like flaxsees and

chia seeds, you have lagoo, luchofanowinal, beans, lentils, tofu, tempay, then you have coffee and tea that are so potent in their anti-inflammatory compounds. You have spices that give flavor and have anti-inflammatory effect. All of this, if it's in your bowl, if it's just super, if it's a sander's, they're great. And, like, we were saying studies have shown that people who eat a healthy dietary pattern, mind diet, they reduce their risk of Alzheimer's, did by 53%, but even if you

actually take some foods that stand out like, for example, studies have shown that people who add one serving of leafy green vegetables, like spinach or kale or colored greens to their diet, right? It could be raw, cooked, frozen, whatever. If they ate that on a regular basis, they had a brain that was in love in years younger. What? What? Yeah. It's just one lame spinach or kale or colored green salad. Just open the bag, fist full of spinach, put it in your soup or just toss

them all away on some lemon on it and just eat it and your brain looks in love in years younger. It looks good on neuro-energy and it functions better as well. How wonderful is that? Just greens.

“Even if somebody is listening to this podcast and the only thing that they take out of this episode”

is just eating leafy green vegetables, I've done my job. I think that's extraordinary. You really have extraordinary. And then you add other things on top of it. Like, for example, if you eat beans on a regular basis, they have so much fiber, they have complex carbohydrates, everybody's scared of carbs, but compits carbohydrates are important for you. Your brain runs on glucose and if you give it the right kind of carbohydrate, it's functions beautifully.

So when you eat lentils and beans that provide protein, they provide compits carbohydrates, it's good for your brain, it's good for your gut, it actually manages your insulin levels, your glucose levels. Because at the end of the day, there are four things that start impacting your brain health. One, it comes to nutrition. Inflammation, oxidation, glucose, sugar, dysregulation, like three diabetes and diabetes. And then lipid dysregulation or five dysregulation,

which means bad cholesterol to high LDL, all of this kind of starts damaging the brain. And would you eat and pack all four of these things? So I would love for the person who's listening to make sure they're having some green leafy vegetables, to make sure that they're having some nuts or seeds. Maybe they can put it in the jar in their counter, add some walnuts to your oats. For them to eat whole grains, like oats, brown rice, let's say quinoa. So them to actually have

some anti-inflammatories in the form of blueberries and strawberries and raspberries. Because these are good compounds that cross the blood brain barrier. And they actually fix the inflammatory changes in the oxidative damage in the brain. For them to drink some coffee if they can handle it, or some mean tea. And you know, I know it sounds cliche, but when they say eat the rainbow,

they really provide the right kind of an environment for your brain to grow and thrive.

I also love that kind of cliche thing, but it's really true to just shop the perimeter of the grocery store because that's where the vegetables and the meats and the fish and all the good stuff are. So Dr. Dean, let's move on to exercise because you have said, well, both of you have said that your legs protect your memory. I don't want to compare exercise to any other

“of the neurofactors, but we're beginning to believe that exercise is central. You have to move.”

You have to create a life of movement because when you move, both aerobic and anaerobic, both exercises that make you tired and exercise that extracting your muscles. Both are now found to be critically important. When you move, believe it or not, it's the number one factor that affects your emotions. Whether it's anxiety, depression, it's an incredibly potent. I'm not saying as a replacement

for medications, but as a powerful adjunct, it's incredibly important. But on the brain itself, when

you move, it creates a chemical such as BDNF, GDNF, and VJ. These are growth factors that grow the vascular, that grow the connections between your arms. They're incredibly powerful. When you move, it's the biggest pump in your body. It's not your heart. It's your legs. Legs push the blood to the brain. So they've done studies that people who moved regularly had better blood flow to the brain. When you move, it actually helps with the cleansing of the brain later on because your lymphatic

system, which is the cleansing mechanism works better. The list goes on and on and on. I don't care if you're going to be, nowadays it's probably let's say zone one and zone this or forget about that. Do a brisk walk. The zone stuff is for people to sell their programs. It's salad greens and walk the brisk walk 20 to 25 minutes a day. That's nothing extraordinary, but it's extraordinary

as far as what it does for you brain. Now the strength exercises are even more powerful,

especially leg exercises. When I was younger, even when you and I worked out, it said, "Don't

“skip leg day. I hated leg day." But leg days are important. Let's start from the other end of”

the life spectrum. When you're older, the number one reason that people end up in the emergency remains falls. In fact, we lost our healthy, incredibly healthy grandma. I should mom adjust recently within last month because of a fall. We lost my mom originally because of a fall in injury and then COVID was a subsequent factor, but falls are incredibly common. Guess what stops falls. Leg sprang. Now let's get a little closer up to a younger age. Leg strength

builds brain fall you. What does that mean? It grows you break. So there's a study, there's a twin study and there's no better studies in twins because genetically they're identical. So it's not genetics. Right. Often even environmentally they're the same, right? Often. They did studies in MCI patients. Mile cognitive repair, pre-dimension. Seeing there's a control group, one sibling did leg strength, the other one did stretching. Not that stretching is bad. But

compared to leg strength, they looked at the percentage of MCI's that went on to develop dementia. Those that they'd leg strength in exercises reduced their chance of Alzheimer's by 47%. Actually, 47%. Leg sprang. Hold on. I just want to make sure that as you're watching or listening, that you really got what Dr. Dean just said to you. So so far, and this makes sense, that your legs are critically important because they're an even bigger pump of blood than your heart.

And when you have good leg strength, when you go for a walk, 25 minute, brisk walk, five days a week, you reduce your risk for Alzheimer's by how much? So the siblings who exercised and had stronger legs, 47% of them actually had normal memory testing after that period. And it wasn't even extensive. It was just a six month study and they exercised for about 30 to 45 minutes. And they were doing things like resistors training, leg press, lunges, and squat. How many days a week

do I have to do this three or four times a week? That's it. Yeah. Like, why wouldn't you do this? If you knew that you decreased your risk for Alzheimer's significantly and if you have any type of mild cognitive impairment, the study is showing that you might actually reverse it? Yeah.

“Well, then that's what I'm saying. Like, as a whisper, I'm like, really? Yes. Yeah.”

The speakers in our hands just yelling at a top of our lungs to say,

Yes. You don't have to do leg presses with weights on your shoulder. I tell people do many squats. You're watching your favorite show, make that your leg day. Stand up. Your couch is behind you. Don't go all the way 90 degrees. Go 60 degrees and do a few of those. Write it down. And even if you follow your five following on your count, but you've started. You've started

“in a place, not a gym where you have to get all dressed up in your own home.”

And find your favorite show. You just attend squats. Or if you're waiting for your microwave, if you're warming something up, instead of just like standing there, just hold on to something and do some mini squats for 60 seconds. And you'll see the back fits.

The simple is this is incredible. Dr. Dean, let's move on to the third one.

We've done nutrition. We've done exercise. The next one is unwind and it's about the intentional effort to destress. Correct. There's a reason why you was in the middle of neuro. As I said earlier, it's stress management is central. But here's the thing, there's good stress and bad stress and good stress is critical. There's a reason that you have 86 billion neurons and a quadrillion connections. If it was reproduction and getting food,

you would stop as a bacteria. They do great job. They get food and they reproduce. It's for more than that. That drained the man's good stress. It needs to be challenging. If I study the show that people who are very mentally active and then they retire and then for the next two years, they didn't do anything. Guess what the steepest decline done. But we've seen it. Yeah. Like you've probably seen your parents retire or somebody in

your family retire and they were active and alive and interested in gauge. And then tears, I was like, who are you? Yes. But the ones that maintain the level, the same level of

activity. But maybe one thing that they always wanted to, right? They maintain the cognitive

capacity. So about though the unwind, why is it important to really take minimizing the bad stress, constant pressure, the negative self-talk, the endless perfectionism and the to-do list, that things that we do that we may be able to dial down. Why is unwinding that stress really important and how do we do it for brain health? Because stress used to be a one-time thing or less frequent, right? The tiger was after you, right? You either died or stressed, right? Or both.

And then now in the modern world, every single system in your body is affected because when you're under stress, your body is telling you, I don't have time enough energy to spend on this. This and this, these are a luxury state. My entire focus is going to be on survival. Yes.

“And everything shuts out. That's why people in chronic stress have hired degrees of cancers.”

Immune system is lower, right? So that's why it's critical to address stress centrally.

And how do you recommend when it comes to brain health, Dr. Dean? What is one important thing that somebody should really start to think about or to do in their life for better brain health when it comes to stress? Very, very non-nerological way. Make lists. Okay. Identify bad stressors in your life. Meaning activities, behaviors and thoughts that are not driven by your purpose, that are external to your purpose, that don't have good timelines, that are just taking

over your life and you are no control over them. Literally write them down specifically. The other side of the paper, write the good stressors. The activities that you would want to do or you're doing that have meaning for you, that have purpose, that are well defined, that have clear timelines of victory, write those down specifically. And your life purpose should be reducing, eliminating, and delegating the negative stress, increasing, empowering, and tooling,

and strategizing towards good stress. But I love the fact that you're talking about lists because you're right. We do tend to manage it all in our minds and we began this conversation by you saying that we are living in a moment in time when there's so much bombarding you

“that your speed of retrieval for what matters is slowing down because you have to wait through”

all this junk that the world is throwing at your brain. And so making the list forces you to get on paper what's actually going on in your life. If you really get intentional around dialing down the stress, what are the implications for slowing down dementia, or growing a better brain, like what happens? At purpose, good stress is activities, behavior, and thoughts that are driven by your purpose. Let's just take that one component. Yes studies have shown that people

that were purpose-driven have significant better brain help. I want to make sure that I demystify the word purpose. In my case, purpose is neurology. Purpose has direction. Purpose is a

direction, that kind of power pulling it. And you have organized it well. It is the ultimate in good

stress. And it makes sense because, you know, if you think about when you get in a rut in your life, where you're just in a period where everything is work, or everything is taking care of other people, and then you start slipping into these habits where you're wasting hours every day on social media and just doing dumb things that actually kind of stress you out, make it depressed. You start telling yourself, "Well, I don't have time to volunteer at hospice. I don't have time to go to

church or synagogue or mosque this weekend. I don't have time to work in the community garden." And the list and getting everything going on in your life and crossing off some stressors also opens up space for you to find a Thursday night to go back to book club. And, you know, I kind of think about this like, "Do you have something you're looking forward to every week?" And that direction is really important. You're saying, "For your brain health." Yes.

“Dr. Isha, let's talk about our rest. How can the person listening improve the quality of their sleep?”

It's so important. I feel like a hypocrite right now talking to you about restoratively because I flew in from Los Angeles last night and I haven't had a good night sleep, but I'm caffeinated. Sleep is something we don't talk about enough and it's always an afterthought. Isn't it? It's like, "Aw, sleep later." It's as if you're taking away time from such a precious thing and you're being selfish to go to sleep, but sleep is a time when your brain actually does

its most important task. Two things happen when we sleep. The first thing that happens is

you actually start cleansing your brain. There's a very elegant system that gets activated when we go to the deeper stages of sleep. It's called the "glimfatic system." And it is made of a type of a fluid that literally washes your brain and gets rid of the debris and there are very specialized cells. There are these tiny cells called microglia. These are the janitor cells of your brain. They get activated. You know how when you're in a building and during the day, there is

business and people come and go. There's a pile of trash that accumulates in the trash cans. This janitorial system comes into the building and then it cleans up. So when you come back the next day, everything is spotless and clean and it smells great, has exactly what happens when we go to sleep. Your brain gets rid of all of the debris, the amyloid beta protein that has been associated with Alzheimer's disease, the towel tangles, and so many other things they get wash away.

The second thing that happens is your memories get organized from short-term to long-term memory.

You know how during the day when you come up with ideas, you write them, you scribbled them, you were scribbling on some papers and the corners, and you probably has a posted notes in your computer and your office. When we go to sleep, all of this information gets beautiful and written into a nice word document. It goes into the right file and then the folder and then the cabinet. I'm giving examples. So you know where it is the next day. You're not

thinking about like, oh, what was that thought that I had? Where did I put it? Oh, it's neatly

“in the right file folder cabinet. I can retrieve it. That's what happens in her brain.”

The the defragging system of the of the brain actually gets activated during deeper stages. So when we don't sleep, when we don't get at least seven to eight hours of deep sleep, when we don't hit those deeper stages of sleep where this process gets activated, when we keep waking up over and over again because we have to go to the bathroom or if we have sleep out, yeah, or if we have restless legs and drum, or if we are worrying constantly,

we keep waking up because that all of this byproducts, the byproducts they accumulate in the brain. And over a long period of time, they've seen that people who have major sleep disorders, chronic disorders, they are at a higher risk of developing Alzheimer's disease and dementia. Well, it makes perfect sense. And it also ties back to what you were talking about earlier about the speed of recovery that if you're not getting a deep, restful night's sleep and you can't

go through that phase where the brain cleans out the garbage, you're having to sift through it all day long and you also aren't filing away anything that happened in the long-term memory. Is there any recommendation that you have for your patients in terms of like just one thing

“that you could do starting tonight that might help you get a better night's sleep?”

There's so many things that you're here on the internet about sleep. One thing that is extremely helpful and it has been validated by sleep specialists and scientists is choosing to wake up the same day every day. Just set a time to wake up the same time every single day. Why? Because say for example, if you decide to wake up at 7 in the morning or 6 in the morning, even if you haven't had enough sleep the night before that, you're going to slowly and gradually

just wake up at the same time. There's so many other things as well and it's dependent on the

“person as well. So for example, going for a walk first thing in the morning, it resets your”

circadian rhythm, it actually exposes you to sunlight, it gets you to exercise a little bit more so you kind of get tired during the day to go to sleep and then there's some environmental factors as well, making sure that your room is dark, making sure that your bedroom is only for sex and sleep and it's not living room or a dining room or a social gathering place that it's cool, that it's not noisy. All of these environmental factors make us and then for stool management,

that in itself is a huge topic, but cognitive behavioral therapy for insomnia works really well. This is something that people can get help from with a psychologist or a sleep specialist and it kind of helps you shut down that noise that is associated with stress.

What I love about the walk first thing in the morning in terms of resetting your circadian rhythm

is it's a two-first. See I like the bundle things. If you do a 25-minute brisk walk first thing,

“we reset the circadian rhythm and we reduce our risk by 45% for Alzheimer's based on the”

research. See I'm listening. You got let's talk about the final recommendation of the five things in neuro and that is 'O' optimized. Optimize is good stress and it is quick. Your brain wants to be charged. Your brain wants to be creative. The ultimate five product, the ultimate purpose and direction of brain is creativity. Creativity is central and creativity means pushing the brain to do new things and study after study shows that people who kept their

brain active, late in life, actually cool their brain. There are some really cool studies, two studies. One is the nun study. The nun study is a several hundred nuns dedicated their body, their brain, their tissue, their blood cells, and their diaries to science. And after they passed away, their brains were autopsy and analyzed. And they saw that some of the nuns, they all did pretty much the same thing. Some of the nuns despite having significant pathology, lots of shrinkage,

lots of little amoloid and tau, as well as little microvascular, you were normal during love. Another group that had very minimal pathology, pretty full brain, and they had Alzheimer's, right before that. And it wasn't genetics. So what's going on? Why is this group that has so much pathology yet normal? This group that has minimal pathology and already succumb to Alzheimer's, after doing much of their work as for genetics and study and blood tests and everything else,

they looked at their diaries. The group that had significant pathology yet was protected. The diaries demonstrated incredibly complex language. They had greater vocabulary. What does that tell you? Idea density, that means they challenged their brain. They learned more. They pushed themselves to a study more, to learn more, to have more vocabulary. Idea density is a lovely, lovely concept. I said if I am a terrible guitarist,

but if I ever have a band, I'm going to call it Idea density, which is going to be even worse. But nonetheless, it's an incredible concept. The group that succumb, in spite of normal, had much less sophisticated vocabulary, had challenged their brain much less. So what are the top recommendations of things that you can do to challenge your brain? Because I'm

sitting here thinking about some of the people in my life who are like always doing Suduko or the

crossword puzzle or passing word like, are we doing word games? Are we reading? Are we learning new skills? Are we learning languages? What is the biggest bang for the buck in terms of

“keeping your mind active and optimizing the brain's natural desire to create to grow to learn?”

E all of that up. But reality is the more complex the better. We did a meta-analysis. We write papers. We did a meta-analysis a couple of years ago. Looking at everybody else's papers who gave a toss and we looked at the bigger data. And we saw that three things matter. Complexity, purpose, and challenge. What does that mean? Activities that have a purpose for you and have complexly mean multi domains and you're pushing yourself are by far the best.

Is that maybe we could be doing a puzzle as a family? We're great. But learning a musical instrument. So when you're learning guitar, you're reading the notes that your language centers. Okay. You're processing it. It's your uh, uh, profundolo. You're visually processing it. You're accepting it alone. You're actually being creative. It's your pride alone. You're emotionally involved. Uh, if they're listening to me, it's bad. Negative emotion. But for me, it's good emotions. You're

emotionally involved. It's your limbic system. And your dexterity. It's your motor product. It's the entire brain being active at the same time. And that's complexity. It's purpose because I love the music. And what you do is if I for a couple of weeks you learned a Beatles song that has four

if it's a three step dance, next week do five step dance. So real life activities are much more

“meaningful because they serve your purpose. Wow. Anything else that counts reading books,”

book clubs staying active because I know people are going to be like, well, how do I engage my brain? I'm 70. I'm 80. I'm this. I'm the other thing. All of those. All of those have complexity in them, right? Right? But if you're reading, read, recite and rewrite, that gives another level complex. So you just write a book, not a whole book, but a chapter. Now think about it. Process it,

rethink it and rewrite it. That brings the entire brain into a fact. If your book clubs are amazing

because now you're social. Yes. So it's the social interaction, the conversation, the thinking, the processing. There's a incredible thing about dual tasks. So our example, if you're on a treadmill, people that exercise on a treadmill and then they listen to a, now Rob is a podcast, which everybody should do. They actually did significantly better than just exercise alone. So you get a two for if you're walking on a treadmill and you're listening to a podcast because you're expanding your

mind and it makes you think about new things and you're moving your legs, which we now know

“your legs pump all this bloodier brain and it's one of the most important things you can be doing.”

When you're exercising, not only is more blood going to the brain, BDNF, brain drive, newer traffic factory that grows the brain is also being pumped at a time that you're learning

something. So it's more to two for. Yeah. So it's critical that we do these kind of things.

Basically, anything you're doing it, doing it a little more complex. If you're going to do it in social setting, even better, that's your brain growing activity. Well, the thing that I'm so excited about is that it's never too early. It's never too late. I love that your brain isn't judging you. Your brain is like a plant wilting in the corner. It needs water. It needs some sunlight. It needs new proper nutrition exercise. It needs you to manage your stress a little better. Get a good

night's sleep and to be engaging it in ways that you can learn and create and those things alone. Significantly improve your brain health. It pauses dementia. It can slow it down. If you're already there, these are things. The people that you love and that you can start doing right now. I have learned so much from the two of you. It is so cool what you're doing. Dr. Dean, Dr. Isha, what are your parting words? 20 years from now, you're not going to remember

this conversation. But your brain is going to remember the changes that you're going to make today

“and tomorrow. And that's what matters. It could be a walk. It could be joining a book club.”

It could be joining your children or your grandchildren to play games once or twice a week. Those things will determine how you are going to be you in this beautiful story of your life. And your 75, 85, 95, 105-year-old will thank you. Beautiful. I don't know if I can talk that, but I'll you'll contribute to it. Yeah, exactly. A cathedral was not built right away. It was one brick at a time. People forget that because they think it's not enough. It isn't enough. When you're standing

in front of TV during your favorite show and at the beginning, just standing and making small steps

in place. That is profoundly powerful for multiple reasons. One is your reward system, which is built

on dopamine is both reward and movement. There's a reason why dopamine affects both of those. Now you've created the foundation, the first brick that everything else can be built on. That's as powerful as the entire building. You've just started just do that every game. If you just add one serving of greens a day, that's not a brick. That's a wall. That is a wall. A wall of a forest. Now you see that the cathedral, these are the cathedrals you're building with

small, simple, incredible bricks of daily activity that will change your life. Your family's life when they talk about genetic is not genetics. It's shared the habits. You've just changed your children's habits and your parents habits. You've just built cathedrals in your communities. That's our purpose of life. Well, Dr. Dean, Dr. Isha, ladies and gentlemen, the chersizer here. It is a real privilege in life to be in the presence of someone's genius.

And it's so moving to see your passion and the gift that you have for boiling all of this down in both a simple way and in an urgent way. I believe you when you say that there are small things

brain health. And you have taught me so much today. I'm sharing this not only with my family

“group chat with Chris and the three adult kids, but the larger ones with cousins and ants and uncles,”

because everybody deserves this information and research and these simple recommendations and the reasons why they matter so much. It's literally your life. And you've just put the power back in our hands to improve it. So thank you. Thank you. Thank you for the work that you're doing. And thank you for flying all the way here and spending this time with us to help us improve our lives. And I want to thank you. Thank you for making the time to listen to something that 1,000% is going to improve

“your life and the life of absolutely everybody that you love that you share this with. I am convinced”

that the way that you take care of your brain is going to determine how you feel in your life. I learned so much. I know you did too. I want to thank you for listening and watching all the way to the end. I also want to thank you for sharing this generously because we all deserve to have access to this

information and the reasons why the things that these amazing doctors are recommending are going

to work. And in case no one else tells you today, I want to be sure to tell you that I love you

“and I believe in you and I believe in your ability to create a better life. And paying attention”

to and taking your brain health seriously, there is no doubt based on the research and everything you learned today that that is the way you create a better life. Alrighty, I will see you in the very next episode. I'm going to welcome you in the moment you hit play. That will either slow down pause or even reverse. That will either slow down pause and even reverse

brain decline. What you're about to all that a second, do we want to do the and everything that the

two medical experts that you're going to meet are going to recommend. They've spent decades studying neuro-generate disease. Oh my god. Dear god, okay, here we go. They are also a married couple who have trained and worked at some of the most prestigious agate prestigious. Okay, I'm so grateful that you're here. I'm also grateful for our sponsors. So I want to take a pause so we can give our chance. Sighting new research and a protocol that can help you slow down pause and even reverse brain

brain decline. Yeah, even reverse brain decline. Well done, Newton. Oh, and one more thing. I know this is not a blooper. This is the legal language. You know what the lawyers write and what I need to read to you. This podcast is presented solely for educational and entertainment purposes. I'm just your friend. I am not a licensed therapist and this podcast is not intended as a substitute for the advice of a physician, professional coach, psychotherapist or

other qualified professional. Got it? Good. I'll see you in the next episode.